ChemicalBook > CAS DataBase List > 4'-Hydroxypropiophenone

4'-Hydroxypropiophenone

Product Name:
4'-Hydroxypropiophenone
CAS No.
70-70-2
Chemical Name:
4'-Hydroxypropiophenone
CBNumber:
CB8854142
Molecular Formula:
C9H10O2
Formula Weight:
150.17
MOL File:
70-70-2.mol
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4'-Hydroxypropiophenone Property

Melting point:
36-38 °C(lit.)
Boiling point:
152-154 °C26 mm Hg(lit.)
Density 
1.09 g/cm3 (20℃)
FEMA 
2005 | ACETANISOLE
refractive index 
1.5360 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
methanol: 0.1 g/mL, clear
pka
8.87±0.26(Predicted)
Water Solubility 
0.34 g/l (15 ºC)
Merck 
14,7044
BRN 
907511
CAS DataBase Reference
70-70-2(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA Substance Registry System
1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38
Safety Statements 
37-24/25-36-26
WGK Germany 
3
RTECS 
UH1925000
TSCA 
Yes
HS Code 
29145000
Hazardous Substances Data
70-70-2(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 11800 mg/kg
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N-Bromosuccinimide Price More Price(6)

Sigma-Aldrich Gold
Product number:
H55405
Product name :
4′-Hydroxypropiophenone
Purity:
98%
Packaging:
100g
Price:
$43.7
Updated:
2019/12/02
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Buy
Sigma-Aldrich Gold
Product number:
8.20692
Product name :
4'-Hydroxypropiophenone for synthesis. CAS 70-70-2, chemical formula 4-(OH)C H COC H ., for synthesis
Packaging:
8206920100
Price:
$44.8
Updated:
2019/12/02
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TCI Chemical Gold
Product number:
H0299
Product name :
4'-Hydroxypropiophenone
Purity:
>98.0%(GC)
Packaging:
25g
Price:
$25
Updated:
2019/12/02
Buy:
Buy
TCI Chemical Gold
Product number:
H0299
Product name :
4'-Hydroxypropiophenone
Purity:
>98.0%(GC)
Packaging:
500g
Price:
$150
Updated:
2019/12/02
Buy:
Buy
Alfa Aesar Gold
Product number:
A15314
Product name :
4'-Hydroxypropiophenone, 99%
Packaging:
500g
Price:
$169
Updated:
2019/12/02
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Buy
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4'-Hydroxypropiophenone Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

gonadotropic hormone inhibitor

Uses

p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.

Uses

Intermediates of Liquid Crystals

Preparation

Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).

Safety Profile

Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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4'-Hydroxypropiophenone Suppliers

Global(342)Suppliers
J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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TCI (Shanghai) Development Co., Ltd.
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Beijing dtftchem Technology Co., Ltd.
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