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Hexamethyldisilazane

Product Name:
Hexamethyldisilazane
CAS No.
999-97-3
Chemical Name:
Hexamethyldisilazane
CBNumber:
CB9105784
Molecular Formula:
C6H19NSi2
Formula Weight:
161.39
MOL File:
999-97-3.mol
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Hexamethyldisilazane Property

Melting point:
-78 °C
Boiling point:
125 °C(lit.)
Density 
0.774 g/mL at 25 °C(lit.)
vapor density 
4.6 (vs air)
vapor pressure 
20 hPa (20 °C)
refractive index 
n20/D 1.407(lit.)
Flash point:
57.2 °F
storage temp. 
2-8°C
solubility 
Miscible with acetone, benzene, ethyl ether, heptane and perchloroethylene.
form 
Liquid
pka
30(at 25℃)
color 
Colorless
Specific Gravity
0.774
Odor
Ammonia odour
PH Range
8.5
explosive limit
0.8-25.9%(V)
Water Solubility 
REACTS
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
Sensitive 
Moisture Sensitive
Merck 
14,4689
BRN 
635752
InChIKey
FFUAGWLWBBFQJT-UHFFFAOYSA-N
CAS DataBase Reference
999-97-3(CAS DataBase Reference)
NIST Chemistry Reference
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-(999-97-3)
EPA Substance Registry System
Hexamethyldisilazane (999-97-3)
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Safety

Hazard Codes 
F,C,Xn
Risk Statements 
11-20/21/22-34-52/53
Safety Statements 
16-26-36/37/39-45-61
RIDADR 
UN 3286 3/PG 2
WGK Germany 
2
RTECS 
JM9230000
21
Autoignition Temperature
325 °C
Hazard Note 
Flammable
TSCA 
Yes
HS Code 
2931 90 00
HazardClass 
3
PackingGroup 
II
Hazardous Substances Data
999-97-3(Hazardous Substances Data)
Toxicity
LDLO i.p. in mice: 650 mg/kg (Petrarch Systems Inc. Product Information Sheets)
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N-Bromosuccinimide Price More Price(32)

Sigma-Aldrich Gold
Product number:
379212
Product name :
Hexamethyldisilazane
Purity:
ReagentPlus , 99.9%
Packaging:
25ml
Price:
$40.4
Updated:
2019/12/02
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Sigma-Aldrich Gold
Product number:
33350-U
Product name :
HMDS, Derivatization Grade
Packaging:
u
Price:
$53.1
Updated:
2019/12/02
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TCI Chemical Gold
Product number:
H0089
Product name :
1,1,1,3,3,3-Hexamethyldisilazane
Purity:
>96.0%(GC)
Packaging:
25mL
Price:
$13
Updated:
2019/12/02
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Buy
TCI Chemical Gold
Product number:
H0089
Product name :
1,1,1,3,3,3-Hexamethyldisilazane
Purity:
>96.0%(GC)
Packaging:
100mL
Price:
$27
Updated:
2019/12/02
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Buy
Alfa Aesar Gold
Product number:
A15139
Product name :
Hexamethyldisilazane, 98+%
Packaging:
100ml
Price:
$27.8
Updated:
2019/12/02
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Hexamethyldisilazane Chemical Properties,Usage,Production

Reaction

Hexamethyldisilazane(HMDS) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.One of the advantages of Hexamethyldisilazane over chlorosilanes is that no base is needed as a hydrochloric acid acceptor. It produces ammonia which escapes easily from the reaction mixture during silylation.

Description

Hexamethyldisilazane is a bulk organo silicon compound, being a quite useful silanizing agent. It is a reagent for the preparation of trimethylsilyl derivatives. It can be used for silanizing the surface of silicon water, cellulose. It can also be used to dehydrate cells of biomaterials for scanning electron microscopy (SEM). The hexamethyldisilazane coatings on various nanoparticles make them be resistant to water contamination and flocculation during synthesis. It can also be used as a modifier to control the shape, formation of agglomerates surface area and pore size of silica particles. Moreover, it is an adhesion promoter for photoresist in photolithography, and is also useful in the pyrolysis-gas chromatography-mass spectrometry to enhance the detectability of compounds with polar functional groups.

Chemical Properties

Colorless liquid

Uses

A reagent for the preparation of trimethylsilyl derivatives.

Uses

Deactivation of chromatographic support materials. In electronic industry as an adhesion promoter for photoresists on silicon.

Uses

Hexamethyldisilazane mainly used as methyl silane alkylation (such as amikacin, penicillin, cephalosporins and kinds of penicillin derivatives), hydroxyl protectants of antibiotics. It is used as surface treatment agent of diatomite, white carbon black, titanium and blond additives of photoresist in the semiconductor industry. It is used as treatment agent of tearing strength resistance. It is used as a solvent in organic synthesis and organometallic chemistry. It is used as an adhesion promoter for photoresist in photolithography. it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical point drying during sample preparation in electron microscopy. It is added to analyte to get silylated diagnostic products during pyrolysis in gas chromatography- mass spectrometry.

Definition

ChEBI: An N-silyl compound obtained from ammonia by replacement of two of the hydrogens with trimethylsilyl groups. Hexamethyldisilazane is a derivatisation agent used in gas chromatography mass spectrometry applications.

General Description

A liquid. Boiling point of 260°F. Flash point 77°F. May be toxic by ingestion. Irritates skin and eyes. Vapors are heavier than air. May emit highly toxic nitrogen oxide fumes when heated to decomposition. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Moisture sensitive.

Reactivity Profile

Hexamethyldisilazane reacts with many carbonyl containing organic compounds to generate gaseous ammonia. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, moderate fire risk.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Purification Methods

A possible impurity is Me3SiCl. Wash it well with pet ether and fractionate it through a vacuum jacketed column packed with Helipac using a reflux ratio of 10:1. [Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4014.]

References

Deng, Xiang. "Hexamethyldisilazane." Synlett 2011.06(2011):881-882. Chiavari, G, D. Fabbri, and S. Prati. "Gas chromatographic-mass spectrometric analysis of products arising from pyrolysis of amino acids in the presence of hexamethyldisilazane." Journal of Chromatography A922.1–2(2001):235-241.
Nation, J. L. "A new method using hexamethyldisilazane for preparation of soft insect tissues for scanning electron microscopy." Stain Technology 58.6(1983):347-51.
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Hexamethyldisilazane Suppliers

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Alfa Aesar
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999-97-3, HexamethyldisilazaneRelated Search:

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