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Flumazenil

Product Name:
Flumazenil
CAS No.
78755-81-4
Chemical Name:
Flumazenil
CBNumber:
CB9208108
Molecular Formula:
C15H14FN3O3
Formula Weight:
303.29
MOL File:
78755-81-4.mol
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Flumazenil Property

Melting point:
201-203°C
Boiling point:
528.0±50.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO to 25mM
form 
solid
pka
0.86±0.20(Predicted)
color 
white
Water Solubility 
128 mg/L
Merck 
14,4135
CAS DataBase Reference
78755-81-4(CAS DataBase Reference)
NIST Chemistry Reference
Flumazenil(78755-81-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-27-36/37/39
WGK Germany 
2
RTECS 
NI2922170
HS Code 
2933997500
Toxicity
LD50 in mice, rats (mg/kg): 4000, 1360 i.p.; 4300, 6000 orally (Hunkeler)
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N-Bromosuccinimide Price More Price(12)

Sigma-Aldrich Gold
Product number:
F6300
Product name :
Flumazenil
Purity:
>99% (HPLC), solid
Packaging:
25mg
Price:
$313
Updated:
2019/12/02
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Sigma-Aldrich Gold
Product number:
1273808
Product name :
Flumazenil
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
200mg
Price:
$1751.75
Updated:
2019/12/02
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TCI Chemical Gold
Product number:
F0958
Product name :
Flumazenil
Purity:
>99.0%(GC)
Packaging:
25mg
Price:
$70
Updated:
2019/12/02
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Buy
TCI Chemical Gold
Product number:
F0958
Product name :
Flumazenil
Purity:
>99.0%(GC)
Packaging:
100mg
Price:
$204
Updated:
2019/12/02
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Alfa Aesar Gold
Product number:
J62537
Product name :
Flumazenil, 98%
Packaging:
500mg
Price:
$1025
Updated:
2019/12/02
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Flumazenil Chemical Properties,Usage,Production

Description

Flumazenil is a benzodiazepine antagonist useful as a fast-acting antidote in the treatment of benzodiazepine intoxication, and in reversing the central sedative effects of benzodiazepines during anesthesia.

Chemical Properties

Colourless crystals

Originator

Hoffmann-La Roche (Switzerland)

Uses

A benzodiazepine antagonist

Uses

Imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.

Uses

beta-blocker, antihypertensive

Uses

benzodiazepine antagonist sedation reversal drug

Definition

ChEBI: An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an ntidote to benzodiazepine overdose.

brand name

Romazicon (Roche);Anexate.

Biological Activity

Benzodiazepine antagonist, non-selective for α 1, α 2, α 3 or α 5-containing GABA A receptors. Centrally active upon systemic administration in vivo .

Veterinary Drugs and Treatments

Flumazenil may be useful for the reversal of benzodiazepine effects after either therapeutic use or overdoses. Flumazenil may be of benefit in the treatment of encephalopathy in patients with severe hepatic failure.

Flumazenil Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

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Flumazenil Suppliers

Global(220)Suppliers
Wuhan Biocause Pharmaceutical Development Co., Ltd..
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027-84222527
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Shanghai Yu Ben Biotechnology Co., Ltd.
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CHINA
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J & K SCIENTIFIC LTD.
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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86-21-50328109
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China
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15881
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Chembest Research Laboratories Limited
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021-20908456-
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021-58180499
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sales@BioChemBest.com
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China
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Suzhou haiyu Biochem Industrial Co., LTD
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Ascent Scientific
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Jia Xing Isenchem Co.,Ltd
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Pure Chemistry Scientific Inc.
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United States
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78755-81-4, FlumazenilRelated Search:

FLUMAZENIL ACID 1-(4-FLUOROPHENYL)IMIDAZOLE N-[(3-fluorophenyl)methyl]ethanamine Flumazenil Methyl acrylate Kresoxim-methyl Urethane fluoro jade Triethyl orthoformate Ethyl chloroformate Basic Violet 1 2,6-Dimethyl-7-octen-2-ol Methanol Ethyl formate 1-Methylimidazole Methyl Methylparaben Paraquat dichloride
  • Flumazenil、Flumazepil
  • FlumazenilUsDmf
  • ANEXATE
  • Flumazepil
  • FMZ
  • Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-α][1,4]benzodiazepine-3-carboxylate
  • Lanexat
  • Mazicon
  • Rcr-15-1788
  • Romazicon
  • Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate
  • 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
  • YM-684
  • Flumazenil (200 mg)
  • ethyl 8-fluoro-5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]iMidazo[1,5-a][1,4]diazepine-3-carboxylate
  • FluMenazil
  • Ro 15-1788/000
  • Ro 1722
  • Ro 41-8157
  • FluMazenil API
  • FluMazenil(Ro 15-1788)
  • ethyl 12-fluoro-8-Methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate
  • 1-4-Amino-3-chloro-5-(trifluoromethyl)phenyl eth Flumazenil
  • Flumazenil, 99.5%
  • ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
  • Flumazenil78755-81-4
  • 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
  • ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
  • FLUMAZENIL
  • 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZO-DIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER
  • 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL EST
  • 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-, ETHYL ESTER
  • RO 15-1788
  • FluMazenil USP
  • 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
  • 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
  • 78755-81-4
  • 78775-81-4
  • 78755-8104
  • C15H14FN3O3
  • antagonist
  • API
  • Active Pharmaceutical Ingredients
  • GABA/Glycine receptor
  • GABA
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • ZEBETA
  • Other APIs