Chemical Properties
Light yellow to brown flakes
Uses
2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.
Uses
Intermediate, medicine.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007
DOI: 10.1021/jo070189y
General Description
2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.
Biochem/physiol Actions
2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.
Purification Methods
Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]
