Actinomycin D suppliers

Actinomycin D

CAS:: 50-76-0

MF:: C62H86N12O16

MW:: 1255.42

SecurityInformation

Symbol(GHS) ：: GHS06,GHS08

Signal word ：: Danger

Hazard statements ：: H300-H350-H360FD

Precautionary statements ：: P201-P202-P264-P270-P280-P301+P310

Hazard Codes ：: T+

Risk Statements ：: 28-61-40-45-26/27/28

Safety Statements ：: 53-36/37/39-45-1-36/37-28-22

RIDADR ：: UN 3462 6.1/PG 2

WGK Germany ：: 3

RTECS ：: AU1575000

F ：: 8-10-21

HazardClass ：: 6.1(a)

PackingGroup ：: II

HS Code ：: 29419000

Toxicity：: LD50 oral in rat: 7200ug/kg

Use：: Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumor activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumor cell death has been demonstrated to occur by apoptosis.

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