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ChemicalBook >> CAS DataBase List >>Cladribine

Cladribine suppliers

Cladribine

CAS:: 4291-63-8

MF:: C10H12ClN5O3

MW:: 285.69

SecurityInformation

Symbol(GHS) ：: GHS06,GHS08

Signal word ：: Danger

Hazard statements ：: H301-H341-H361fd-H372

Precautionary statements ：: P201-P202-P260-P264-P270-P301+P310

Hazard Codes ：: T

Risk Statements ：: 36/37/38-23/24/25

Safety Statements ：: 26-37/39-45-36-22

RIDADR ：: UN 2811 6.1 / PGIII

WGK Germany ：: 3

RTECS ：: AU7357560

HS Code ：: 29349990

Toxicity：: LD50 intraperitoneal in mouse: 150mg/kg

Use：: Cladribine, an adenosine deaminase inhibitor, was introduced in the United States as a single intravenous treatment for hairy cell leukemia. The incorporation of a chlorine atom at the 2-position of deoxyadenosine renders cladribine more resistant to enzymatic attack by adenosine deaminase, resulting in a more prolonged cytotoxic effect. Cladribine efficiently crosses lymphocyte and monocyte cell membranes and is metabolized in cells to the biologically active triphosphate, which inhibits DNA synthesis. While most antineoplastic drugs are active primarily against dividing cells, cladribine destroys both resting and proliferating cells. Its potential uses in the treatment of autoimmune hemolytic anemia, multiple sclerosis, chronic lymphocytic leukemia and various lymphomas have also been evaluated.

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You can find Cladribine suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

CONIER CHEM AND PHARMA LIMITED