α-Naphthoflavone suppliers

α-Naphthoflavone

CAS:: 604-59-1

MF:: C19H12O2

MW:: 272.3

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302-H413

Precautionary statements ：: P264-P270-P273-P301+P312-P330

Hazard Codes ：: Xi,Xn,C,F

Risk Statements ：: 68-34-11

Safety Statements ：: 24/25-36/37-45-36/37/39-26-16

WGK Germany ：: 3

RTECS ：: QL6250000

F ：: 8

Hazard Note ：: Irritant

TSCA ：: Yes

HS Code ：: 29143990

Use：: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]

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Hebei Mojin Biotechnology Co., Ltd