SERTINDOLE
106516-24-9 Basic informationMore
- Product Name:SERTINDOLE
- Synonyms: SERTINDOLE SUBSTANCE 5364890 1-(2-{4-[5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOL-3-YL]-PIPERIDIN-1-YL}-ETHYL)-IMIDAZOLIDIN-2-ONE 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone 1-(4-Fluorophenyl)-5-chloro-3-[1-[2-[(tetrahydro-2-oxo-1H-imidazol)-1-yl]ethyl]piperidin-4-yl]-1H-indole 1-[2-[4-[1-(4-Fluorophenyl)-5-chloro-1H-indole-3-yl]piperidino]ethyl]imidazolidine-2-one S-1991 LU-23-174
- CAS:106516-24-9
- MF:C24H26ClFN4O
- MW:440.94
- EINECS:
- Mol File:106516-24-9.mol
-
USE
Serdolect was launched in the UK for acute and chronic schizophrenia and
schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l-
(4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain
and has a high affinity for the serotinin 5-HT<sub>2</sub> receptor where it behaves as an
antagonist. It has weak affinity for the α<sub>1</sub>-adrenergic receptor and no affinity for
dopamine D<sub>2</sub> receptors. It is as effective as haloperidol but without the
extrapyramidal symptoms. This may be a consequence of the fact that it expresses
the c-fos protein in a manner different for haloperidol but similar to clozapine. It is
non-sedating, long lasting (several days after a single dose) and has an atypical
mode of action.
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- Company Name:Shanghai Rochi Pharmaceutical Co., Ltd.
- Tel:021-38751876 15000076078
- Products Intro:Product Name:Sertindole
CAS:106516-24-9
Purity:99%min Package:1kg 5kg 10kg 25kg More... - CB Index:55
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Sertindole
CAS:106516-24-9
Package:2.5Mg,25Mg More... - CB Index:76
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- Company Name:Chemvon Biotechnology Co., Ltd
- Tel:021-50790412
- Products Intro:Product Name:Sertindole
CAS:106516-24-9
Purity:99% HPLC Package:1g;50g;100g;1kg More... - CB Index:57
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Sertindole
CAS:106516-24-9
Purity:95.0% LC Package:10MG,50MG More... - CB Index:81
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- Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel:0571-82693216
- Products Intro:CAS:106516-24-9
More... - CB Index:52
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