ChemicalBook >  Product Catalog >  Chemical Reagents >  Silane reagent >  N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Basic information Safety Related Supplier

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Basic information

Product Name:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
CAS:
24589-78-4
MF:
C6H12F3NOSi
MW:
199.25
EINECS:
246-331-6
Mol File:
24589-78-4.mol
More
Less

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties

Melting point:
98-100°C
Boiling point:
130132°C
Density 
1.075 g/mL at 25 °C(lit.)
vapor density 
>1 (vs air)
vapor pressure 
8.8 mm Hg ( 27 °C)
refractive index 
n20/D 1.383
Flash point:
77 °F
storage temp. 
2-8°C
pka
-1.34±0.70(Predicted)
form 
Liquid
color 
Clear colorless to light yellow
Specific Gravity
1.076
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
BRN 
1941550
InChIKey
MSPCIZMDDUQPGJ-UHFFFAOYSA-N
CAS DataBase Reference
24589-78-4(CAS DataBase Reference)
EPA Substance Registry System
Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4)
More
Less

Safety Information

Hazard Codes 
Xi,F,T,N
Risk Statements 
10-36/37/38-61-50/53-51/53
Safety Statements 
26-36-37/39-16-45-53-61
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
AC9800000
10-21
Hazard Note 
Flammable
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29319090

MSDS

More
Less

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Usage And Synthesis

Chemical Properties

Clear colorless to light yellow liquid

Uses

A new metabolite of Famprofazone in humans.

Uses

pharmaceutical intermediate

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.

Purification Methods

Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

More
Less

N-Methyl-N-(trimethylsilyl)trifluoroacetamideSupplierMore

Shanghai Qiao Chemical Science Co., Ltd Gold
Tel:
021-58892003- ;021-50396381
Email:
info@qiaochem.com;aaron@qiaochem.com;
Aikon International Limited Gold
Tel:
025-66151770,13813800073//qq:2885670560
Email:
lwan@aikonchem.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
Basic information Safety Related Supplier