ChemicalBook >  Product Catalog >  API >  Antipyretic analgesics >  Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >  Aceclofenac

Aceclofenac

Basic information Description Mechanism of Action Precautions Safety Related Supplier

Aceclofenac Basic information

Product Name:
Aceclofenac
CAS:
89796-99-6
MF:
C16H13Cl2NO4
MW:
354.18
EINECS:
641-844-5
Mol File:
89796-99-6.mol
More
Less

Aceclofenac Chemical Properties

Melting point:
149-153°C
Boiling point:
486.0±45.0 °C(Predicted)
Density 
1.455±0.06 g/cm3(Predicted)
RTECS 
CY1577900
storage temp. 
-20°C Freezer
solubility 
Soluble in DMSO
pka
2.60±0.10(Predicted)
form 
powder
color 
off-white to light tan
Water Solubility 
32mg/L(32 ºC)
Merck 
14,22
InChIKey
MNIPYSSQXLZQLJ-UHFFFAOYSA-N
CAS DataBase Reference
89796-99-6(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester (89796-99-6)
More
Less

Safety Information

Hazard Codes 
T,N
Risk Statements 
25-36-50/53
Safety Statements 
26-45-60-61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29224999
More
Less

Aceclofenac Usage And Synthesis

Description

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.

Mechanism of Action

Aceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.

Precautions

Before taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.

Description

Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.

Chemical Properties

White Crystalline Solid

Originator

Prodes (Prodesfarma) (Spain)

Uses

Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.

Definition

ChEBI: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

brand name

Airtal; Gerbin

Aceclofenac Preparation Products And Raw materials

Raw materials

More
Less

AceclofenacSupplierMore

J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
TAIYUAN RHF CO.,LTD.
Tel:
+86 351 7031519
Email:
sales@RHFChem.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Energy Chemical
Tel:
021-58432009
Email:
sales8178@energy-chemical.com
Basic information Description Mechanism of Action Precautions Safety Related Supplier