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Diethylene glycol

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Diethylene glycol Basic information

Product Name:
Diethylene glycol
CAS:
111-46-6
MF:
C4H10O3
MW:
106.12
EINECS:
203-872-2
Mol File:
111-46-6.mol
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Diethylene glycol Chemical Properties

Melting point:
−10 °C(lit.)
Boiling point:
245 °C(lit.)
Density 
1.118 g/mL at 25 °C(lit.)
vapor density 
2.14 (vs air)
vapor pressure 
0.01 mm Hg ( 20 °C)
refractive index 
n20/D 1.447(lit.)
Flash point:
143 °C
solubility 
H2O: 50 mg/mL at 20 °C, clear, colorless
form 
Oily Liquid
pka
14.03±0.10(Predicted)
color 
colorless
Relative polarity
0.713
Odor
Practically odorless.
PH
5.5-7.0 (25℃, 50mg/mL in H2O)
explosive limit
2-12.3%
Water Solubility 
SOLUBLE
FreezingPoint 
-10.45℃
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: ≤0.02
λ: 280 nm Amax: ≤0.01
Merck 
14,3119
BRN 
969209
InChIKey
MTHSVFCYNBDYFN-UHFFFAOYSA-N
CAS DataBase Reference
111-46-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethanol, 2,2'-oxybis-(111-46-6)
EPA Substance Registry System
Diethylene glycol (111-46-6)
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Safety Information

Hazard Codes 
Xn,T,Xi
Risk Statements 
22
Safety Statements 
46
WGK Germany 
1
RTECS 
ID5950000
10
Autoignition Temperature
442 °F
Hazard Note 
Toxic/Irritant
TSCA 
Yes
HS Code 
29094100
Hazardous Substances Data
111-46-6(Hazardous Substances Data)
Toxicity
LD50 in rats, guinea pigs (g/kg): 20.76, 13.21 orally (Smyth)

MSDS

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Diethylene glycol Usage And Synthesis

Chemical Properties

Diethylene glycol is a clear colorless, odorless and stable oily liquid. It is also slightly viscous, noncorrosive and nonvolatile. Because of its ether and alcohol group, diethylene glycol exhibits chemical properties characteristic of both primary alcohols and ethers. Its boiling point is considerably higher than that of ethylene glycol, and its solvent is greater. Diethylene glycol is miscible with water, ethers, lower aliphatic alcohols, aldehydes and ketones and is partially soluble in benzene, carbon tetrachloride, monobenzene, orthodichlorobenzene and toluene. It dissolves many dyes, resins, oils, nitrocellulose and many organic substances. Because of its solvent power, low volatility and hygroscopicity, it is used in textile lubricants, cutting oils, dry cleaning soap, printing inks, steam-set inks, and nongrain wood stains. In the textile industry diethylene glycol is used as a conditioning agent for wool, rayon, and cotton. As a solvent for dyes it makes a valuable assistant in dyeing and printing. The high hygroscopicity of diethylene glycol makes it an efficient softening agent for tobacco, paper, synthetic sponges, glues and casein. Diethylene glycol is especially useful in the dehydration of natural gas. A mixture of diethylene glycol and monoethanolamine will remove moisture, hydrogen sulfide and carbon dioxide from natural gas.
diethylene glycol structure
diethylene glycol structure

Uses

In antifreeze solution for sprinkler systems, water seals for gas tanks, etc. (water with 40% diethylene glycol freezes at -18°; with 50% at -28°); as lubricating and finishing agent for wool, worsted, cotton, rayon, and silk; as solvent for vat dyes; in composition corks, glues, gelatin, casein, and pastes to prevent drying out.

Uses

Diethylene glycol is a colorless, odorless, clear liquid. It is miscible with water in any ratio. It has many industrial uses. It is a component of antifreeze, brake fluids, cosmetics, inks, and drying agents, and it is used as a plasticizer.

Production Methods

Diethylene glycol is produced commercially as a by-product of ethylene glycol production. It can also be produced directly by reaction between ethylene glycol and ethylene oxide .

General Description

A colorless liquid. Denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Diethylene glycol is incompatible with strong oxidizing agents. Diethylene glycol is also incompatible with strong bases. Diethylene glycol can react with sulfuric acid and other dehydrating agents, nitric acid, oxygen, hydrogen peroxide, perchloric acid and strong acids. Mixtures with sodium hydroxide decompose exothermically when heated to 446° F.

Health Hazard

Ingestion of large amounts may cause degeneration of kidney and liver and cause death. Liquid may cause slight skin irritation.

Fire Hazard

Diethylene glycol is combustible.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pert.

Toxicology

The toxicity of diethylene glycol is similar to ethylene glycol and clearly is a CNS depressant. It has a low inhalation hazard because of its low vapor pressure; however, inhalation of the mist or aerosol is to be avoided. Workplace levels for vapors and aerosols cannot exceed 50 ppm. In case of accidental release of diethylene glycol, use of a full-face positive air pressure respirator is recommended. Even though the toxicokinetics in humans is not completely understood, its toxic nature is confirmed by animal studies. Several human cases were reported in the medical literature. Several children in Haiti died in 1995 and 1996 following the consumption of medication containing diethylene glycol. Similar other cases in children were reported in other countries as well. A 24-year-old man developed encephalopathy and rapidly became quadriplegic following ingestion of a solution containing diethylene glycol . Thus, the toxicity of diethylene glycol is well established.

Safety Profile

Moderately toxic to humans by ingestion. Poison experimentally by inhalation. Moderately toxic by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic,tumorigenic, and teratogenic data. An eye and human skin irritant. Combustible when exposed to heat or flame; can react with oxidning materials. To fight fire, use alcohol foam, water, Con, dry chemical. Mixtures with sodium hydroxide decompose exothermically when heated to 230℃ and release explosive hydrogen gas. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.

Carcinogenicity

Weil et al. , in their longterm studies on rats of three different age levels, found only one bladder tumor in those fed diets that contained 4% diethylene glycol. This tumor was in a rat that also had bladder stones . To clarify the question of the cause of the tumor, Weil et al. implanted calcium oxalate stones or glass beads into the bladders of rats. They found that bladder tumors never developed without the presence of a foreign body in the bladder. This led to the conclusion that diethylene glycol essentially free of ethylene glycol is not a primary carcinogen.

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