基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MSDS 羰基氰化氯苯腙 价格(试剂级) 供应商 供应信息 相关产品
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羰基氰化氯苯腙

羰基氰化氯苯腙

英文名称:CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
CAS号:555-60-2
分子式:C9H5ClN4
分子量:204.62
EINECS号:209-103-7
Mol文件:555-60-2.mol
羰基氰化氯苯腙 结构式

羰基氰化氯苯腙 性质

熔点 170-175 °C (dec.)
沸点 333.84°C (rough estimate)
密度 1.3807 (rough estimate)
折射率 1.6110 (estimate)
储存条件 -20°C
溶解度 甲醇:10 mg/mL,澄清,深的黄色
形态 粉末
酸度系数(pKa) 6.00±0.10(Predicted)
颜色 黄色至橙色粘性至蜡状
水溶解性 Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
BRN 1842102
暴露限值 NIOSH: IDLH 25 mg/m3
InChIKey UGTJLJZQQFGTJD-UHFFFAOYSA-N
CAS 数据库 555-60-2(CAS DataBase Reference)
EPA化学物质信息 Propanedinitrile, [(3-chlorophenyl)hydrazono]- (555-60-2)

羰基氰化氯苯腙 用途与合成方法

CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone)是一种氧化磷酸化抑制剂,是线粒体质子载体解偶联剂,可增加线粒体膜对质子的通透性,从而破坏线粒体膜电位。

STING
IFN-β

CCCP inhibits IFN-β production induced by various types of the STING pathway activators. CCCP suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway. CCCP drastically suppresses the production of IFN-β in DMXAA-treated RAW264.7 cells and MEFs.

The same dosage of 3 mg/kg.bw each of CCCP and PPEF is used. In both the cases 1 log reduction is observed in the bacterial load. However, when 3 mg/kg.bw of PPEF is used in combination with 3 mg/kg.bw of CCCP, 6 log 10 reduction is observed in the bacterial count. The developed model validates the enhanced antibacterial activity of combination therapy. 99m Tc-MIBI signals in the hearts of SD rats administered CCCP (4 mg/kg intraperitoneally) or vehicle is also measured. 99m Tc-MIBI signals decrease in rat hearts administered CCCP, and the ATP content, as measured by 31 P magnetic resonance spectroscopy, decreased simultaneously. To investigate whether CCCP decreased the 99m Tc-MIBI signals in rats, we analyzed the radioisotope activity of excised heart tissue from rats administered CCCP. At 180 min after 99m Tc-MIBI injection, the 99m Tc-MIBI signals from the hearts in the CCCP group are significantly lower than those in the vehicle group.

安全信息

危险品标志T
危险类别码23/24/25-36/37/38
安全说明26-36/37-45
危险品运输编号UN 2811 6.1/PG 3
WGK Germany3
RTECS号FG5600000
TSCAYes
危险等级6.1
包装类别III
海关编码29280090

MSDS信息

语言:English
提供商:ACROS
语言:English
提供商:SigmaAldrich
语言:Chinese
提供商:ALFA
语言:English
提供商:ALFA

羰基氰化氯苯腙 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-100941 10 mg 250
2024-01-25 HY-100941 羰基氰化氯苯腙 555-60-2 50mg 500

羰基氰化氯苯腙供应商 更多

宁波市超明生物科技有限公司(原上海清柳化工有限公司)
黄金产品
联系电话:3429815786 13301662590
产品介绍:
CAS:555-60-2
纯度:98% HPLC
包装信息:1G;5G;10G;25G;50G;100G,1KG;25KG;50KG
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
中文名称:羰基氰基3-氯苯腙/羰基氰化氯苯腙/CCCP
英文名称:Carbonyl cyanide 3-chlorophenylhydrazone, 99+%
CAS:555-60-2
纯度:99+%
包装信息:1GR, 100MG
备注:化学试剂、精细化学品、医药中间体、材料中间体
上海迈瑞尔生化科技有限公司
联系电话:4006608290; 18621169109
产品介绍:
英文名称:Carbonyl cyanide 3-chlorophenylhydrazone
CAS:555-60-2
纯度:99+%
备注:22813
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
中文名称:羰基氰化氯苯腙
英文名称:CCCP;Carbonylcyanide3-chlorophenylhydrazone
CAS:555-60-2
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
阿法埃莎(中国)化学有限公司
联系电话:400-6106006
产品介绍:
中文名称:羰基氰酯-3-氯苯基腙, 98%
英文名称:Carbonyl cyanide 3-chlorophenylhydrazone, 98%
CAS:555-60-2
包装信息:100Mg
备注:L06932

羰基氰化氯苯腙生产厂家及价格列表

羰基氰酯-3-氯苯基腙
成都彼样生物科技有限公司 2024-03-26
羰基氰化氯苯腙 555-60-2
怀化市冰峰化工有限公司 2024-03-22

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