ChemicalBook >  Product Catalog >  Biochemical Engineering >  Natural Products >  Cianidanol

Cianidanol

Basic information Safety Related Supplier

Cianidanol Basic information

Product Name:
Cianidanol
CAS:
154-23-4
MF:
C15H14O6
MW:
290.27
EINECS:
205-825-1
Mol File:
154-23-4.mol
More
Less

Cianidanol Chemical Properties

Melting point:
175-177 °C (anhydrous)(lit.)
alpha 
D18 +16 to +18.4°
Boiling point:
352.36°C (rough estimate)
Density 
1.2451 (rough estimate)
refractive index 
1.4359 (estimate)
storage temp. 
2-8°C
pka
9.54±0.10(Predicted)
form 
neat
Merck 
14,1902
InChIKey
PFTAWBLQPZVEMU-DZGCQCFKSA-N
CAS DataBase Reference
154-23-4
EPA Substance Registry System
2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- (154-23-4)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DJ3450000
8-10-23
HS Code 
29329990
Toxicity
LD50 oral in rat: > 10gm/kg

MSDS

More
Less

Cianidanol Usage And Synthesis

Chemical Properties

Tan Solid

Uses

procollagen production inhibitoe, hepatoprotectant

Uses

(+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Uses

Labelled (+)-Catechin (C217500). (+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Uses

Cianidanol, also known as (+)-catechin; (+)-3,3′4′,5,7-flavanepentol; 3,3′,4′, 5,7-pentahydroxyflavane, [R,3S]-2-[3,4-dihydroxyphenyl]-3,4-dihydro-1[2H]- benzopyran-3,4,7-triol, or 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h- 1-benzopyran-7-triol, is a flavonoid associated with a variety of blood disorders. An association of cianidanol and immune hemolytic anemia and thrombocytopenia has been suggested in numerous case reports. In several reports, the presence of flavonoid-dependent antibodies against red blood cells is evident with cianidanol combining with erythrocyte membranes and inducing development of autoantibodies and antibodies.Several patients had platelet antibodies with increased serum-bindable IgG values without the presence of cianidanol and several with high platelet-associated IgG levels.Antibodies against cianidanol were not detectable in certain cases.The hemolytic anemia caused acute renal failure in some patients and can be life threatening, leading to fatalities. Upon cessation of treatment with cianidanol, hematology appears to return to normal over time.
These side effects do not appear to be specific to cianidanol as the formation of IgE and IgG antibodies to troxerutin (Venoruton) and silymarin (Kegalon) was also evident with patients presenting with fever, skin eruptions, and intravascular hemolysis often demonstrating high IgG titers.Furthermore, cianidanol-induced hemolysis might also occur after sensitization by other flavonoids including rutin.

Definition

ChEBI: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.

brand name

Ausoliver;Cirramina;Transepar.

World Health Organization (WHO)

Cianidanol, which is extracted from the tropical plant Uncaria gambir, was introduced in 1976 as an adjunct in the treatment of liver disorders. Following a cluster of cases of haemolytic anaemia reported in 1985 from Naples, Italy, four of which were fatal, the company suspended sales worldwide. Although subsequently reintroduced in Switzerland and France for the treatment of acute and chronic hepatitis-B, it was later definitively withdrawn in Switzerland on detailed reassessment and the manufacturer has now withdrawn the product worldwide.

Cianidanol Preparation Products And Raw materials

Preparation Products

More
Less

CianidanolSupplierMore

Raw material medicin reagent co.,Ltd Gold
Tel:
025-57798860
Email:
sales@njromanme.com
Beijing Jin Ming Biotechnology Co., Ltd. Gold
Tel:
010-60605840-
Email:
psaitong@jm-bio.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
Basic information Safety Related Supplier