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BUTYRONITRILE

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BUTYRONITRILE Basic information

Product Name:
BUTYRONITRILE
CAS:
109-74-0
MF:
C4H7N
MW:
69.11
EINECS:
203-700-6
Mol File:
109-74-0.mol
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BUTYRONITRILE Chemical Properties

Melting point:
−112 °C(lit.)
Boiling point:
115-117 °C(lit.)
Density 
0.794 g/mL at 25 °C(lit.)
vapor density 
2.4 (vs air)
vapor pressure 
23 mm Hg ( 25 °C)
refractive index 
n20/D 1.384(lit.)
Flash point:
62 °F
storage temp. 
Flammables area
solubility 
slightly soluble in water; soluble in alcohol, ether and dimethylformamide
form 
Liquid
color 
Clear
Water Solubility 
Miscible with benzene, alcohol, ether and dimethylformamide. Slightly soluble in water.
Merck 
14,1597
BRN 
1361452
Exposure limits
TLV-TWA 22.5 mg/m3 (8 ppm) (NIOSH).
Stability:
Stable. Combustible. Substances to be avoided include strong acids, strong bases, strong oxidizing agents and strong reducing agents.
CAS DataBase Reference
109-74-0(CAS DataBase Reference)
EPA Substance Registry System
Butanenitrile (109-74-0)
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Safety Information

Hazard Codes 
T,F
Risk Statements 
10-23/24/25-11
Safety Statements 
45-63-36/37-16
RIDADR 
UN 2411 3/PG 2
WGK Germany 
1
RTECS 
ET8750000
Autoignition Temperature
910 °F
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29269095
Toxicity
LD50 orally in rats: 0.14 g/kg (Smyth)

MSDS

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BUTYRONITRILE Usage And Synthesis

Chemical Properties

colourless liquid

Chemical Properties

n-Butyronitrile has a sharp suffocating odor. Forms cyanide in the body.

Uses

Butyronitrile is used as a chemical intermediate.

Uses

Basic material in industrial, chemical, and pharmaceutical intermediates and products; poul- try medicines.

Definition

ChEBI: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a propyl group.

Production Methods

n-Butyronitrile is prepared from 1-butanol by controlled cyanation with NH3 at 300°C in the presence of Ni-Al203 or zinc phosphide catalysts.

General Description

A clear colorless liquid. Flash point 76°F. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used in the manufacture of other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

BUTYRONITRILE can react vigorously with oxidizing reagents, when heated to decomposition, BUTYRONITRILE emits highly toxic fumes of cyanides and oxides of nitrogen [Sax, 9th ed., 1996, p. 609]. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Hazard

Flammable, dangerous fire risk.

Health Hazard

Dizziness, rapid respirations, headache, drowsiness, drop in blood pressure and pulse, delayed symptoms. May cause cyanosis (blue-grey coloring of skin and lips due to lack of oxygen)

Health Hazard

n-Butyronitrile is considered a highly hazardous material and full precautions should be used to prevent skin contact or inhalation of the vapor. Inhaled n-butyronitrile is about 2.4 times as toxic as acetonitrile. In order to protect workers, the recommended TWA limit is obtained by dividing that for acetonitrile by the factor 2.4. NIOSH has therefore recommended that employee exposure should not exceed 8 ppm (v/v) (22 mg/m3) compound as a TLV-TWA.

Health Hazard

Butyronitrile showed moderate to high toxicity on test animals. It is an acute toxicant by all routes: inhalation, ingestion, and absorption through skin. The target organs are the liver, kidney, central nervous system, lungs, and sense organs, as well as the peripheral nerve. Its toxicity is on the same order as that of propionitrile; its inhalation toxicity is slightly lower than that of propionitrile, and its oral toxicity is slightly greater than that of propionitrile.
Inhalation can cause nausea, respiratory distress, and damage to liver. Willhite (1981) reported a LC50 value of 249 ppm in mice from 1 hour exposure to its vapor. It produced ataxia, dyspnea, and corneal damage in test animals when given intraperitoneally. The toxic symptoms from subcutaneous applications are tremor, dyspnea, respiratory depression, and spastic paralysis. It is toxic only at low levels by skin absorption.
LD50 value, oral (mice): 27.7 mg/kg
There is no report on its teratogenicity. The reproductive effect of this compound is expected to be similar to that of propionitrile.

Fire Hazard

Special Hazards of Combustion Products: Toxic cyanide fumes

Industrial uses

n-Butyronitrile is used as an industrial solvent, an intermediate in the chemical industry and in poultry medicines.

Safety Profile

A poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. Moderately toxic by inhalation. Experimental reproductive data. A skin irritant. Dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx and CN-.

Purification Methods

Treat it with conc HCl until the smell of the isonitrile had gone, then dry with K2CO3 and fractionally distil [Turner J Chem Soc 1681 1956]. Alternatively it is twice heated at 75o and stirred for several hours with a mixture of 7.7g Na2CO3 and 11.5g KMnO4 per L of butyronitrile. The mixture is cooled, then distilled. The middle fraction is dried over activated alumina. [Schoeller & Wiemann J Am Chem Soc 108 22 1986, Beilstein 2 IV 806.]

Waste Disposal

Burning in a chemical incinerator equipped with an afterburner and scrubber is the most effective way to destroy the compound. Oxidation with ethanolic–KOH can convert butyronitrile to nonhazardous cyanate.

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