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Phloroglucinol

Basic information Feature reaction of phloroglucinol Chemical properties Uses Production method Hazards & Safety Information Safety Related Supplier

Phloroglucinol Basic information

Product Name:
Phloroglucinol
CAS:
108-73-6
MF:
C6H6O3
MW:
126.11
EINECS:
203-611-2
Mol File:
108-73-6.mol
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Phloroglucinol Chemical Properties

Melting point:
215-220 °C
Boiling point:
194.21°C (rough estimate)
Density 
0.801 g/mL at 20 °C
refractive index 
n20/D 1.365
Flash point:
14 °C
storage temp. 
Dark Room
solubility 
Soluble in diethyl ether, ethanol and pyridine.
pka
pK1:8.45(0);pK2:8.88(-1) (25°C)
form 
Crystalline Powder
color 
White to light beige
Water Solubility 
11.17g/L(room temperature)
Sensitive 
Light Sensitive & Hygroscopic
Merck 
14,7328
BRN 
1341907
InChIKey
QCDYQQDYXPDABM-UHFFFAOYSA-N
CAS DataBase Reference
108-73-6(CAS DataBase Reference)
NIST Chemistry Reference
1,3,5-Benzenetriol(108-73-6)
EPA Substance Registry System
1,3,5-Benzenetriol (108-73-6)
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Safety Information

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38-34-43
Safety Statements 
7-16-24/25-45-36/37/39-26-36/37-37/39
RIDADR 
UN 1170 3/PG 2
WGK Germany 
2
RTECS 
SY1050000
TSCA 
Yes
HS Code 
29072900
Toxicity
LD50 in mice, rats (g/kg): 4.7, 4.0 i.g. (Cahen)

MSDS

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Phloroglucinol Usage And Synthesis

Feature reaction of phloroglucinol

Reaction of formaldehyde with phloroglucinol under alkaline conditions generates orange compound. The colorimetric assay determination of this compound at the maximum absorption wavelength of 460 nm, can be used to detect low or trace formaldehyde in textile and garment.
Since phloroglucinol may occur enol and keto tautomers, it can react with ammonia according following reaction:
Under the influence of ammonia, 1,3,5-Benzenetriamine can be obtained by keto reaction of phloroglucinol
Under the influence of ammonia, 1,3,5-Benzenetriamine can be obtained by keto reaction of phloroglucinol, while this amine can also hydrolyze in aqueous acid to generate phloroglucinol. Besides phloroglucinol can also have enol reaction.
phloroglucinol can also have enol reaction
The information above is edited by Andy from Chemicalbook.

Chemical properties

This product is a white or light yellow crystal or crystalline powder with melting point of 218 ℃. Usually it carries two molecular crystallization water ([6099-90-7]) and converts into anhydrous at 110 ℃. It can be dissolved in 100 parts of water, 10 parts of ethanol, and 0.5 parts of pyridine and is soluble in ether. Besides It partially decomposes when sublimation, and changes its color when exposed to the light. In addition it tastes sweet.

Uses

It can be used in verifications of antimony, arsenic, cerium, chromate, chromium, gold, iron, mercury, nitrites, osmium, palladium, tin, vanadium, vanillin and lignin, and measurement of furfural, pentose, pentosan, methanol, chloral hydrate, turpentine, Lignified cell tissues, free acid in gastric juice (HCl) and decalcified bone specimens. Besides it can also be used as biological reagent dyes.

Production method

2,4,6-aminobenzoic acid can be obtained by 2,4,6-trinitrobenzoic acid`s reduction of zinc particles. After its dilute solution was heated at reflux for 20h, acidified with hydrochloric acid, cooled and crystallized, phloroglucinol can be obtained with a yield of 46-53%.

Hazards & Safety Information

Category: Toxic substances
Toxicity grade: Moderate toxicity
Acute toxicity: oral-rat LD50: 4000 mg/kg; Oral-Mouse LD50: 4550 mg/kg
Flammability hazard characteristics: Combustible fire burning can cause smoke irritation
Storage characteristics: Ventilated, low-temperature and dry warehouse; and separately with oxidants
Extinguishing agents: Carbon dioxide, foam, sand and water mist

Chemical Properties

white to light yellow crystal

Uses

Antispasmodic.

Uses

Phloroglucinol (1,3,5-trihydroxybenzene) is the core structure of a large family of substituted phenolics with broad, albeit weak, biological activity. Phloroglucinol is a useful metabolite for HPLC/DAD and bioassay dereplication.

Uses

diagnostic aid growth hormone releasing factor

Uses

A potentially useful hygroscopic biochemical.

Definition

ChEBI: A benzenetriol with hydroxy groups at position 1, 3 and 5.

Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in diazo-type printing and textile dyeing, in microscopy as a bone specimen decalcifier

Purification Methods

Crystallise the triol from water, and store it in the dark under nitrogen. [Beilstein 6 IV 7361.]

Phloroglucinol Preparation Products And Raw materials

Preparation Products

Raw materials

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PhloroglucinolSupplierMore

-Jiangsu Dingye Pharmaceutical Co., Ltd. Gold
Tel:
0515-87666666-
Email:
13905116808@139.com
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CAS:108-73-6
Huainan Kedi Chemical Factory Gold
Tel:
0554-2106669
Email:
sales1@kedichem.com
Products Intro:
CAS:108-73-6
Taixing Haorui Technology Co., Ltd. Gold
Tel:
18136939580
Email:
chemical_china@hotmail.com
Products Intro:
Product Name:phloroglucinol
CAS:108-73-6
Purity:99.8%
Shanghai demo pharmaceutical technology co., LTD Gold
Tel:
400-021-7337
Email:
1563259405@qq.com
Products Intro:
CAS:108-73-6
Purity:0.98 Package:25KG
Wuhan xinyangruihe Chemical Technology Co., Ltd. Gold
Tel:
027-83850375-
Email:
669797270@qq.com
Products Intro:
Product Name:Phloroglucinol
CAS:108-73-6
Purity:98%;99% Package:1公斤;25公斤;100公斤;吨位
Basic information Feature reaction of phloroglucinol Chemical properties Uses Production method Hazards & Safety Information Safety Related Supplier