Cholexamine,Kyorin,Japan,1971
To a mixture of 60 cc of benzene, 40 cc of pyridine and 17 g of hydrochloric
acid salt of nicotinic acid chloride, was added 4.5 g of 2,2,6,6-
tetramethylolcyclohexanol, and the whole mixture was refuxed at 75°C to
80°C for 2.5 hours. After the mixture was cooled water was added. Precipitate
formed was separated by filtration, washed thoroughly with water and dried.
Recrystallization from dilute acetic acid gave 14 g of the final compound,
melting point 177°C to 180°C.
