Propranolol was responsible for sensitisation of workers
in drug synthesis. In one case, epichlorhydrin was
used for the production of both propranolol and
oxprenolol.
Colorless crystals.Soluble in
water and alcohol; insoluble in benzene and ether.
Cardiac depressant (anti-arrhythmic); anti-adrenergic
(β-receptor).
β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
ChEBI: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Major indications of propranolol, and of
many other β-blockers, include coronary heart
disease, hypertension, and cardiac arrhythmias.
These β-blocking agents are mainly used in
arrhythmias accompanied by increased catecholamine
levels, e.g., excitement, stress, or hyperthyroidism
.
Inderal (Wyeth); Innopran (Reliant).
Propranolol is a beta-blocking agent that was responsible
for the sensitization of workers in drug synthesis.
In one case, epichlorhydrin was used for the production
of drugs propranolol and oxprenolol. Crossreactivity
is expected between beta-blockers.
