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10,11-Dimethoxystrychnine

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10,11-Dimethoxystrychnine Basic information

Product Name:
10,11-Dimethoxystrychnine
CAS:
357-57-3
MF:
C23H26N2O4
MW:
394.46
EINECS:
206-614-7
Mol File:
357-57-3.mol
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10,11-Dimethoxystrychnine Chemical Properties

Melting point:
175-178 °C (dec.)(lit.)
alpha 
-118 º (c=2.5 in chloroform)
Boiling point:
518.67°C (rough estimate)
Density 
1.2119 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
Store at RT
pka
8.28(at 25℃)
form 
Powder
color 
White to light beige
Water Solubility 
Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol
Merck 
14,1455
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
357-57-3(CAS DataBase Reference)
NIST Chemistry Reference
Brucine(357-57-3)
EPA Substance Registry System
Brucine (357-57-3)
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/28-52/53
Safety Statements 
13-45-61
RIDADR 
UN 1570 6.1/PG 1
WGK Germany 
3
RTECS 
EH8925000
TSCA 
Yes
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29399900
Hazardous Substances Data
357-57-3(Hazardous Substances Data)

MSDS

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10,11-Dimethoxystrychnine Usage And Synthesis

Chemical Properties

White powder

Uses

10,11-Dimethoxystrychnine can be used for antineoplastic, convulsant.

Uses

Brucine occurs in the seeds of strychnosspecies (Strychnos nux vomica L. and otherspecies). It is used for denaturing alcoholsand oils; for separating racemic mixtures;and as an additive to lubricants. It is alsoused for colorimetric analysis of nitrate.Therapeutically, it is used as a stimulant.

General Description

A white crystalline solid. Combustible but may require some effort to ignite. Toxic by inhalation (vapor, dust, etc.) and ingestion.

Air & Water Reactions

Slightly soluble in water.

Hazard

Poison by ingestion and inhalation.

Health Hazard

The toxicity of brucine is similar to that ofstrychnine. It is a very poisonous alkaloid. Itis a strong convulsant; excites all portions ofthe central nervous system. Toxic symptomsinclude headache, tremor, muscular rigidity,and convulsions. Death may occur fromrespiratory arrest after a few convulsions.
LD50 value, subcutaneous (mice): 60 mg/kg.

Health Hazard

Chemical is toxic if inhaled, swallowed, or absorbed through skin. Inhalation produces intense bitter taste. Ingestion causes nausea, vomiting, restlessness, excitement, twitching, and (rarely) convulsions. Contact with dust irritates eyes.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.

Agricultural Uses

Rodenticide: Used in the manufacture of other chemicals, in perfumes, as a medication for animals, and as a poison for rodents

Trade name

DOLCO MOUSE CEREAL®; PIED PIPER MOUSE SEED® (Brucine)

Safety Profile

A poison by subcutaneous, intravenous, and intraperitoneal routes. An alkaloid-like strychnine, but one-sixth as toxic. When heated to decomposition it emits toxic fumes of Nx,. See also STRYCHNINE

Purification Methods

Crystallise brucine once from water or aqueous Me2CO (as the tetrahydrate), then suspend it in CHCl3 and shake with anhydrous Na2SO4 (to dehydrate the brucine, which then dissolves). Precipitate it by pouring the solution into a large bulk of dry pet ether (b 40-60o), filter and heat to 120o in a high vacuum [Turner J Chem Soc 842 1951]. The tetrahydrate crystallises from a mixture of EtOH and H2O as colourless elongated needles [Eeles Acta Cryst 6 809 1953, Beilstein 27 III/IV 7875.] VERY POISONOUS

10,11-Dimethoxystrychnine Preparation Products And Raw materials

Preparation Products

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