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Zopiclone

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Zopiclone Basic information

Product Name:
Zopiclone
CAS:
43200-80-2
MF:
C17H17ClN6O3
MW:
388.81
EINECS:
256-138-9
Mol File:
43200-80-2.mol
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Zopiclone Chemical Properties

Melting point:
1780C
Boiling point:
580.7±50.0 °C(Predicted)
Density 
1.1105 (estimate)
Flash point:
2℃
storage temp. 
Store at RT
solubility 
DMSO: 2 mg/mL
pka
pKa ﹣1.5±0.1(10% ACN in aq. H2SO4 t = 25.0) (Uncertain)
InChIKey
GBBSUAFBMRNDJC-UHFFFAOYSA-N
CAS DataBase Reference
43200-80-2(CAS DataBase Reference)
NIST Chemistry Reference
Zopiclone(43200-80-2)
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Safety Information

Hazard Codes 
Xn,Xi,F
Risk Statements 
20/21/22-36/37/38-62-36-11
Safety Statements 
26-36-36/37-16
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
TL1425000
HS Code 
29339900
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Zopiclone Usage And Synthesis

Description

Zopiclone is an agonist at the type A γ-aminobutyric acid (GABA) receptor. It is a non-benzodiazepine hypnotic which was first reviewed in Drugs in 1986 and it is indicated for short-term treatment of insomnia. Zopiclone has a relatively low propensity to cause residual clinical effects (such as difficulty in waking or reduced morning concentration).

References

[1] Stuart Noble, Heather D. Langtry and Harriet M. Lamb, Drugs, 1998, vol. 55, 277-302
[2] G. Hajak, W. E. Müller, H. U. Wittchen, D. Pittrow, W. Kirch, Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data, Addiction, 2003, vol. 98, 1371-1378

Description

Zopiclone is an effective hypnotic agent with a short duration of action. Although it interacts with the benzodiazepine receptor complex, it is reported to have minimal effects on memory, little synergy with alcohol, and low abuse potential.

Chemical Properties

Crystalline Solid

Originator

Rhone-Poulenc (France)

Uses

Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic

Uses

antihyperammonemic,antineoplastic

Uses

inhibits tyrosinase and prevents melanin formation used to whiten and lighten skin

Definition

ChEBI: A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.

brand name

IMOVANE

World Health Organization (WHO)

Zopiclone was introduced as a sedative in 1985. It remains registered in several countries and the World Health Organization is not aware of any other country that has refused registration.

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Basic information Description References Safety Related Supplier