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Dehydroepiandrosterone

Basic information Indications and Usage Mechanisms of Action Safety Related Supplier

Dehydroepiandrosterone Basic information

Product Name:
Dehydroepiandrosterone
CAS:
53-43-0
MF:
C19H28O2
MW:
288.42
EINECS:
200-175-5
Mol File:
53-43-0.mol
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Dehydroepiandrosterone Chemical Properties

Melting point:
149-151 °C(lit.)
alpha 
12 º (c=2, ethanol 96% 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
9℃
storage temp. 
Hormones
pka
15.02±0.60(Predicted)
form 
Fine Crystalline Powder
color 
White
Water Solubility 
21.8mg/L(23.5 ºC)
Merck 
2871
BRN 
2058110
InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-N
CAS DataBase Reference
53-43-0
NIST Chemistry Reference
5-Androstene-3«beta»-ol-17-one(53-43-0)
EPA Substance Registry System
Prasterone (53-43-0)
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Safety Information

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
BV8396000
HS Code 
29372900

MSDS

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Dehydroepiandrosterone Usage And Synthesis

Indications and Usage

Dehydroepiandrosterone (DHEA,) chemical name 3β-hydroxy-5alpha-androstane-17-ketone, is an esterifying 3–β–hydroxy steroid retaining 5,6 cholesterol. A white crystalline powder, soluable in ethanol, ether, and benzene, and slightly soluable in chroloform and petroleum ether. Precipitates in digitalis.
DHEA is an estrogen precursor secreted by the reticular layer of the human adrenal cortex. Prevents obesity, resists diabetes, fights cancer, fights cortical disease, and delays senility treats immune deficiencies, promotes the growth and differentiation of bone cells, and promotes the synthesis of protein. It also resists viral infections, improves memory, and relieves nervous tension. DHEA is the main ingredient in steroid hormone intermediates (such as norethindrone and bisacetylene, etc.) and in birth control, and is involved in the secretion of many adrenal hormones. It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.

Mechanisms of Action

DHEA has a thyroid stimulating effect inhibiting food and fat intake and reducing fat accumulation, etc. It improves glucose tolerance, increases insulin level and fights diabetes. It can enhance endocrine system actiity, reduce cortisol levels, and resist a variety of pathological processes. It can help the body obtain cortical antibodies. DHEA has a strong protective and synergistic effect when used to treat tumors, becuase it inhibits ribose 5-phosphate. Inhibits cancer by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate esters. Regulates the growth of pancreatic cancer cells by regulating the concentration of estrogen in blood plasma. A decline in GnRH gene expression leads to aging, and DHEA can restore GnRH neuronal activity, stopping or improving certain diseases associated with declines in DHEA by stimulating GnRH biosynthesis. Restores impaired immune response, improves T- and B-cell function, and plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1,) and is a potentially useful drug for immunodeficiency. DHEA alone cannot directly affect the growth and differential of osteoblasts, but it can do so by influencing 1,25-dihydroxyvitamin D3. The effects of DHEA on bone mass depend on the presence and form of sex hormones in bone cells and their endrocine effects on osteoblasts. DHEA is an anabolic protein hormone which promotes protein synthesis. According to the findings of Marrero and others, feeding DHEA (0.45%) to mice increased liver weight, increasing liver mitochondria by guiding liver protein restoring RNA and protein synthesis.

Chemical Properties

white fine crystalline powder

Occurrence

DHEA is naturally occurring in yam (see Wild Yam, p. 596-597).

Uses

Major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.

Uses

adrenocortical hormone, antidepressant

brand name

17-chetovis 17-hormoforin;Cetavister;Climatost;Dastonil;Dha-s (prasterone);Gynodian;Longevital 5000;Maxepa;Mentalormon;Mylis;Neurocotex;Psicosterone;Ro 66827;Sh 833;Ultrapla.

World Health Organization (WHO)

The World Health Organization has no information further to the above regarding preparations containing prasterone or to indicate that such preparations remain available.

Safety Profile

An experimental teratogen.Experimental reproductive effects. Questionablecarcinogen with experimental neoplastigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Dehydroepiandrosterone Preparation Products And Raw materials

Preparation Products

Raw materials

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DehydroepiandrosteroneSupplierMore

Wuhan Biocar Bio-Pharm Co., Ltd. Gold
Tel:
86 15387057351
Email:
sales@biocar.cn
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% Package:≥10g 50;≥100g 300;≥500g 1100;≥1kg 2000 Remarks:Pharmacopoeial grade
Wuhan Senwayer Century Chemical Co.,Ltd Gold
Tel:
86-27-59707018,027-59009407,18672314556
Email:
sales@senwayer.com
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% HPLC Package:5KG;1KG
Xi'an boliante Chemical Co., Ltd. Gold
Tel:
Email:
3570451756@qq.com
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% Package:10g;100g;1kg;10kg;25kg
Hubei Hongjing Chemical Co., Ltd. Gold
Tel:
027-82333386-
Email:
617019505@qq.com;
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% Package:1KG/1900.00;
Shaanxi billion Kang Long biological technology co., LTD Gold
Tel:
17791478691
Email:
997832940@qq.com
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% Package:1kg 25kg 100kg
Basic information Indications and Usage Mechanisms of Action Safety Related Supplier