ChemicalBook >  Product Catalog >  API >  Hormones and the Endocrine System >  Androgen and anabolic hormones >  Dehydroepiandrosterone

Dehydroepiandrosterone

Basic information description Indications and Usage Mechanisms of Action Safety Related Supplier

Dehydroepiandrosterone Basic information

Product Name:
Dehydroepiandrosterone
CAS:
53-43-0
MF:
C19H28O2
MW:
288.42
EINECS:
200-175-5
Mol File:
53-43-0.mol
More
Less

Dehydroepiandrosterone Chemical Properties

Melting point:
149-151 °C(lit.)
alpha 
12 º (c=2, ethanol 96% 25 ºC)
Boiling point:
370.65°C (rough estimate)
Density 
1.0484 (rough estimate)
refractive index 
1.4709 (estimate)
Flash point:
9℃
storage temp. 
Hormones
pka
15.02±0.60(Predicted)
form 
Fine Crystalline Powder
color 
White
Water Solubility 
21.8mg/L(23.5 ºC)
Merck 
2871
BRN 
2058110
InChIKey
FMGSKLZLMKYGDP-USOAJAOKSA-N
CAS DataBase Reference
53-43-0
NIST Chemistry Reference
5-Androstene-3«beta»-ol-17-one(53-43-0)
EPA Substance Registry System
Prasterone (53-43-0)
More
Less

Safety Information

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
BV8396000
HS Code 
29372900

MSDS

More
Less

Dehydroepiandrosterone Usage And Synthesis

description

Dehydroepiandrosterone (DHEA) is a steroid hormone that is a popular nonprescription oral “dietary supplement” used by men to enhance cognitive function, mood, libido, and athletic performance. Before 1994, DHEA was a prescription medicine. After the passage of the Dietary Supplement Health and Education Act of 1994, DHEA was reclassified as a nutritional supplement. Although sold over the counter in 25- and 50-mg strengths, DHEA is widely touted to maximize results at doses of 200 mg or higher. DHEA is banned by the International Olympic Committee and the National Collegiate Athletic Association as an anabolic agent. Limited information is available regarding potential harmful effects resulting from its supplemental use.

Indications and Usage

Dehydroepiandrosterone (DHEA,) chemical name 3β-hydroxy-5alpha-androstane-17-ketone, is an esterifying 3–β–hydroxy steroid retaining 5,6 cholesterol. A white crystalline powder, soluable in ethanol, ether, and benzene, and slightly soluable in chroloform and petroleum ether. Precipitates in digitalis.
DHEA is an estrogen precursor secreted by the reticular layer of the human adrenal cortex. Prevents obesity, resists diabetes, fights cancer, fights cortical disease, and delays senility treats immune deficiencies, promotes the growth and differentiation of bone cells, and promotes the synthesis of protein. It also resists viral infections, improves memory, and relieves nervous tension. DHEA is the main ingredient in steroid hormone intermediates (such as norethindrone and bisacetylene, etc.) and in birth control, and is involved in the secretion of many adrenal hormones. It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.

Mechanisms of Action

DHEA has a thyroid stimulating effect inhibiting food and fat intake and reducing fat accumulation, etc. It improves glucose tolerance, increases insulin level and fights diabetes. It can enhance endocrine system actiity, reduce cortisol levels, and resist a variety of pathological processes. It can help the body obtain cortical antibodies. DHEA has a strong protective and synergistic effect when used to treat tumors, becuase it inhibits ribose 5-phosphate. Inhibits cancer by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate esters. Regulates the growth of pancreatic cancer cells by regulating the concentration of estrogen in blood plasma. A decline in GnRH gene expression leads to aging, and DHEA can restore GnRH neuronal activity, stopping or improving certain diseases associated with declines in DHEA by stimulating GnRH biosynthesis. Restores impaired immune response, improves T- and B-cell function, and plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1,) and is a potentially useful drug for immunodeficiency. DHEA alone cannot directly affect the growth and differential of osteoblasts, but it can do so by influencing 1,25-dihydroxyvitamin D3. The effects of DHEA on bone mass depend on the presence and form of sex hormones in bone cells and their endrocine effects on osteoblasts. DHEA is an anabolic protein hormone which promotes protein synthesis. According to the findings of Marrero and others, feeding DHEA (0.45%) to mice increased liver weight, increasing liver mitochondria by guiding liver protein restoring RNA and protein synthesis.

Chemical Properties

white fine crystalline powder

Originator

Aslera ,Genelabs Technologies, Inc.

Occurrence

DHEA is naturally occurring in yam (see Wild Yam, p. 596-597).

Uses

Major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.

Uses

adrenocortical hormone, antidepressant

Manufacturing Process

To a solution of 1 gram of 16-dehydropregnenolon-3β-acetate in 10 ml pyridine is added 0.22 gram of hydroxylamine hydrochloride, and the mixture is allowed to stand at room temperature for four days. One gram of 16dehydropregnenolon-3β-acetate oxime is dissolved in 30 ml of hot dioxane, and then the solution is cooled in an ice bath until about one-half of the dioxane has solidified. Then 1 gram of phosphorus pentachloride is added and the mixture is shaken until all the dioxane has melted. The mixture is maintained at 35°C, for seventy-five minutes, then an excess of ice is added and the solution is again allowed to stand at 35°C. After about thirty minutes, a solution of 5 ml of concentrated hydrochloric acid in 10 ml of water is added, and the mixture is diluted with water, extracted with ether and the ethereal extract washed with dilute sodium hydroxide solution. The ether is removed on a steam bath and the residue is worked up to yield dehydroisoandrosterone.

brand name

17-chetovis 17-hormoforin;Cetavister;Climatost;Dastonil;Dha-s (prasterone);Gynodian;Longevital 5000;Maxepa;Mentalormon;Mylis;Neurocotex;Psicosterone;Ro 66827;Sh 833;Ultrapla.

Therapeutic Function

Glucocorticoid

World Health Organization (WHO)

The World Health Organization has no information further to the above regarding preparations containing prasterone or to indicate that such preparations remain available.

Safety Profile

An experimental teratogen.Experimental reproductive effects. Questionablecarcinogen with experimental neoplastigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Dehydroepiandrosterone Preparation Products And Raw materials

Preparation Products

Raw materials

More
Less

DehydroepiandrosteroneSupplierMore

Wuhan Biocar Bio-Pharm Co., Ltd. Gold
Tel:
86 15387057351
Email:
sales@biocar.cn
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% Package:≥10g 50;≥100g 300;≥500g 1100;≥1kg 2000 Remarks:Pharmacopoeial grade
Hubei Hongjing Chemical Co., Ltd. Gold
Tel:
13669024603
Email:
617019505@qq.com;
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:98% Package:1KG/2200.00;
Shaanxi billion Kang Long biological technology co., LTD Gold
Tel:
17791478691 177-9147-8691
Email:
997832940@qq.com
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99% Package:1kg 25kg 100kg Remarks:899KG
ChemCell Biomedicine Co.,Ltd. Gold
Tel:
13556033878
Email:
chemcell@hotmail.com;chemcell@hotmail.com
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:98% Package:50g;100g;250g;500g;1;5kg;10kg
Xi'an Laina Biotechnology Co., Ltd Gold
Tel:
18629577295
Email:
jack@lynabio.com
Products Intro:
Product Name:Dehydroepiandrosterone
CAS:53-43-0
Purity:99%HPLC
Basic information description Indications and Usage Mechanisms of Action Safety Related Supplier