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Trimethylsilyl cyanide

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Trimethylsilyl cyanide Basic information

Product Name:
Trimethylsilyl cyanide
CAS:
7677-24-9
MF:
C4H9NSi
MW:
99.21
EINECS:
231-657-3
Mol File:
7677-24-9.mol
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Trimethylsilyl cyanide Chemical Properties

Melting point:
8-11 °C(lit.)
Boiling point:
114-117 °C(lit.)
Density 
0.793 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.392(lit.)
Flash point:
34 °F
storage temp. 
0-6°C
solubility 
Miscible with organic solvents.
form 
liquid
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
BRN 
1737612
InChIKey
LEIMLDGFXIOXMT-UHFFFAOYSA-N
CAS DataBase Reference
7677-24-9(CAS DataBase Reference)
EPA Substance Registry System
Silanecarbonitrile, trimethyl- (7677-24-9)
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Safety Information

Hazard Codes 
F,T+,T,N
Risk Statements 
11-26/27/28-29-50/53
Safety Statements 
16-36/37/39-45-61-28A-26
RIDADR 
UN 3384 6.1/PG 1
WGK Germany 
3
10-21
Hazard Note 
Highly Flammable/Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29310095

MSDS

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Trimethylsilyl cyanide Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

Reacts with aldehydes and ketones to give cyanohydrin-TMS ethers which can be reduced to β-aminoethyl alcohols.

Uses

Trimethylsilyl Cyanide is used as a reagent in the synthesis of optically active cyanohydrins. Used in the preparation of Reissert compounds, which represent reactive polyamides. Toxic to humans.

Purification Methods

The material should have only one sharp signal in the 1H NMR (in CCl4 with CHCl3 as internal standard) : 0.4ppm and IR with max at 2210cm1 [McBride & Beachall J Am Chem Soc 74 5247 1952, Prober J Am Chem Soc 77 3224 1955]; otherwise purify it by fractionating through an 18 x 1/4inch column. [Evers et al. J Am Chem Soc 81 4493 1959.] It has also been carefully distilled using a 60cm vacuum jacketed column. If the volume of sample is small, the cyanide can be chased (in the distillation) with xylene that had been previously distilled over P2O5. It is HIGHLY TOXIC and FLAMMABLE. [Evans et al. J Org Chem 39 914 1974, Beilstein 4 IV 3893.]

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Nanjing Vital Chemical Co., Ltd. Gold
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010-88425576
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