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Hydroxyapatite

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Hydroxyapatite Basic information

Product Name:
Hydroxyapatite
CAS:
1306-06-5
MF:
Ca5HO13P3
MW:
502.31
EINECS:
215-145-7
Mol File:
1306-06-5.mol
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Hydroxyapatite Chemical Properties

Melting point:
1100 °C(lit.)
Density 
3.076 g/cm3(Temp: 18 °C)
storage temp. 
−20°C
solubility 
H2O: 0.3 mg/mL, clear, colorless
form 
solid
color 
White
Water Solubility 
insoluble H2O [MER06]
Merck 
13,3500
CAS DataBase Reference
1306-06-5(CAS DataBase Reference)
EPA Substance Registry System
Hydroxylapatite (Ca5(OH)(PO4)3) (1306-06-5)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
MY8434000
3-10
TSCA 
Yes
HS Code 
28352600
Hazardous Substances Data
1306-06-5(Hazardous Substances Data)

MSDS

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Hydroxyapatite Usage And Synthesis

Description

Calcium hydroxyapatite has a unique structure in that it is conductive along the hydroxide channels. OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on the c-axis and charge-carrying protons are responsible for the observed conductivities in M10(PO4)6(OH)2. The H+ migration between the electroattractive ion (O2) to give molecular H2O in matrix channels carries charge and the resulting conductivity.
The unit cell consists of two triangular prismatic subcells forming a rhombic prism with vertical sides. There are two horizontal mirror planes at the OH levels of 1/4 and 3/4 of the c-axis. In addition, there is a center of inversion exactly in the center of each vertical face of each subcell.

Chemical Properties

Tricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of a variable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O.

Chemical Properties

white powder

Occurrence

Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.

Uses

Prosthetic aid (artificial bone and teeth).

Uses

In the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.

Preparation

The technical product is also known as “bone ash.” Commercial preparation from phosphate rock.

Definition

The major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth.

brand name

Alveograf (Sterling Winthrop); Periograf (Sterling Winthrop).

Pharmaceutical Applications

Modified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makes up ~50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and a chemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despite similar or identical chemical compositions, the response of the body to these compounds can be quite different.

Hydroxyapatite Preparation Products And Raw materials

Preparation Products

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HydroxyapatiteSupplierMore

AbaChemScene Gold
Tel:
732-484-9848
Email:
sales@chemscene.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
Adamas Reagent, Ltd.
Tel:
400-600-9262
Email:
bxy@titansci.com
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