To the mixture of 2.89 g (18.2 mmol) sodium 2-
aminobenzoate, 40 mL acetic acid and 2.31 g (9.1 mmol) molecular iodine, 5 mL
(44.1 mmol, 30 wt %) aqueous hydrogen peroxide was added drop wise. The
S3
reaction mixture was stirred at 50 °C for 3 h and poured into 400 mL water. The
formed crystals were filtered and recrystallized from benzene to give 2-azido-5-
iodobenzoic acid . IR (suspension in nujol, cm−1
): 3500, 3387, 1670, 1612, 1580,
1541, 1419, 1377, 1319, 1290, 1163, 1125, 813, 688, 619.
2-Amino-5-iodobenzoic acid is used in wide range of medicals industrial applications as well as in human and animal nutrition products such as pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.
