ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Amide >  N-Bromosuccinimide

N-Bromosuccinimide

Basic information Safety Related Supplier

N-Bromosuccinimide Basic information

Product Name:
N-Bromosuccinimide
CAS:
128-08-5
MF:
C4H4BrNO2
MW:
177.98
EINECS:
204-877-2
Mol File:
128-08-5.mol
More
Less

N-Bromosuccinimide Chemical Properties

Melting point:
175-180 °C (dec.)(lit.)
Boiling point:
221.4°C (rough estimate)
Density 
2.098
vapor pressure 
14.8 hPa (20 °C)
refractive index 
1.6060 (estimate)
storage temp. 
0-6°C
solubility 
14.8g/l (decomposition)
pka
-2.78±0.20(Predicted)
form 
Crystalline Powder
color 
White to light yellow
Water Solubility 
Soluble in acetone, tetrahydrofuran, dimethyl formamide, dimethyl sulfoxide and acetonitrile. Slightly soluble in water and acetic acid. Insoluble in ether, hexane and carbon tetrachloride.
Sensitive 
Moisture Sensitive
Merck 
14,1438
BRN 
113916
Stability:
Stable. Incompatible with strong oxidizing agents, halogenated hydrocarbons.
InChIKey
PCLIMKBDDGJMGD-UHFFFAOYSA-N
CAS DataBase Reference
128-08-5(CAS DataBase Reference)
NIST Chemistry Reference
2,5-Pyrrolidinedione, 1-bromo-(128-08-5)
EPA Substance Registry System
N-Bromosuccinimide (128-08-5)
More
Less

Safety Information

Hazard Codes 
C,Xn
Risk Statements 
22-34-36/37/38
Safety Statements 
26-36/37/39-45-37/39
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
Hazard Note 
Harmful
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29251995
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg

MSDS

More
Less

N-Bromosuccinimide Usage And Synthesis

Chemical Properties

white to light yellow crystalline powder

Uses

N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis.

Uses

NBS, is a chemical reagent used in organic chemistry in electrophilic addition reactions and radical substitution

Uses

In bromination of olefins; in oxidation of alcohols to aldehydes and ketones and of aldehydes to acid bromides.

Definition

ChEBI: A five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom.

Safety Profile

Poison by intraperitoneal route. An irritating poison to skin, eyes, and mucous membranes. Reacts explosively with adme, dtallyl sulfide, and hydrazine hydrate. Explosive reaction with propiononitrile after heating to 105℃ for 24 hours. Violent reaction with dtbenzoyl peroxide + 4-tok acid. When heated to decomposition it emits toxic fumes of Brand NOx. See also BROMIDES and NITROGEN MONOXIDE.

Purification Methods

N-Bromosuccinimide (30g) is purified by dissolving rapidly in 300mL of boiling water and filtering through a fluted filter paper into a flask immersed in an ice bath, and left for 2hours. The crystals are filtered off, washed thoroughly with ca 100mL of ice-cold water and drained on a Büchner funnel before drying under vacuun over P2O5 or CaCl2 [Dauben & McCoy J Am Chem Soc 81 4863 1959]. This brominating agent has also been crystallised from acetic acid or water (10 parts), washed in water and dried in vacuo [Wilcox et al. J Am Chem Soc 108 7693 1986, Shell et al. J Am Chem Soc 108 121 1986, Phillips & Cohen J Am Chem Soc 108 2013 1986, Beilstein 21/9 V 543.]

N-Bromosuccinimide Preparation Products And Raw materials

Preparation Products

Raw materials

More
Less

N-BromosuccinimideSupplierMore

Nanjing Apicci Pharmaceutical Technology Co., Ltd. Gold
Tel:
Email:
Hanyd2019@apicci.com
Nantong jianru chemical co. LTD Gold
Tel:
0513-69887633
Email:
2673140726@qq.com
Alfa Aesar Gold
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
ShangHai Zexin Chemical Technology Co., Ltd. Gold
Tel:
15901897992,13052395209,021-60136491
Email:
jianglijuan101@163.com,sales@zexinchem.cn
Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel:
021-20337333/400-620-6333
Email:
sale@aladdin-e.com
Basic information Safety Related Supplier