五味子丙素
五味子丙素 性质
| 熔点 | 122-123℃ |
|---|---|
| 沸点 | 549.2±50.0 °C(Predicted) |
| 密度 | 1.232 |
| 溶解度 | DMSO：8.33 mg/mL（21.67 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 粉末 |
| 颜色 | 白色 |
| LogP | 5.623 (est) |
五味子丙素 用途与合成方法
Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).
Western Blot Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Decreased the expression of apoptosis related proteins. |
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced cell apoptosis. |
Cell Cycle Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced growth inhibition and G1 arrest of U937 cells. |
Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously.
| Animal Model: | Aβ1-42-induced Alzheimer’s disease mice |
| Dosage: | 15-150 μg/kg |
| Administration: | Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days |
| Result: | Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice. |
