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Nabumetone

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Nabumetone Basic information

Product Name:
Nabumetone
CAS:
42924-53-8
MF:
C15H16O2
MW:
228.29
Mol File:
42924-53-8.mol
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Nabumetone Chemical Properties

Melting point:
80-810C
Boiling point:
330.1°C (rough estimate)
Density 
1.0657 (rough estimate)
refractive index 
1.5542 (estimate)
storage temp. 
Refrigerator
solubility 
Soluble in alcohol or chloroform
form 
neat
CAS DataBase Reference
42924-53-8(CAS DataBase Reference)
NIST Chemistry Reference
Nabumetone(42924-53-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-40
Safety Statements 
36/37
WGK Germany 
2
RTECS 
EL9085000
HS Code 
2914500000

MSDS

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Nabumetone Usage And Synthesis

Description

Nabumetone is a non-acidic, nonsteroidal antiinflammatory agent formally related to naproxen. Its main circulating metabolite is 6-methoxy-2-naphthylacetic acid (α-nornaproxen). Administered once daily (Tsub>1/2 * 30 hrs), nabumetone is reported to be effective in the treatment of rheumatoid and osteoarthritis.

Chemical Properties

White Powder

Originator

Beecham (United Kingdom)

Uses

Anti-inflamatory. Antibacterial

Uses

Anti-inflammatory. Antibacterial.

Uses

anesthetic (local)

Definition

ChEBI: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is s own to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.

Indications

Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor that is chemically similar to naproxen. As with most NSAIDs, GI side effects are most commonly reported. The incidence of gastric ulceration is lower with nabumetone than with many other NSAIDs.This is due to its nature as a prodrug, not to COX-2 selectivity. Lower-bowel complaints, rashes, and CNS disturbances are common adverse effects.

brand name

Relafen (Smith-Kline Beecham);RELIFEX.

General Description

Nabumetone (Relafen), a nonacidic NSAID prodrug, isclassified as an arylacetic acid, because it undergoes rapidhepatic metabolism to its active metabolite, 6-methoxy-2-naphthylacetic acid. Similar to the other arylacetic aciddrugs, it is used in short- or long-term management of RAand OA. Being nonacidic, it does not produce significantprimary insult to the GI mucosa lining and also has no effecton prostaglandin synthesis in gastric mucosa, thus producingminimum secondary GI damage when comparedwith other conventional NSAIDs.

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NabumetoneSupplierMore

J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:
3bsc@sina.com
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel:
13817811078,021-50426030
Email:
sales@jingyan-chemical.com
LGM Pharma
Tel:
1-(800)-881-8210
Email:
inquiries@lgmpharma.com
Nanjing Chemlin Chemical Co., Ltd
Tel:
025-83697070
Email:
sales@chemlin.com.cn
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