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Lynestrenol

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Lynestrenol Basic information

Product Name:
Lynestrenol
CAS:
52-76-6
MF:
C20H28O
MW:
284.44
EINECS:
200-151-4
Mol File:
52-76-6.mol
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Lynestrenol Chemical Properties

Melting point:
158°C
alpha 
D -13° (chloroform)
Boiling point:
366.92°C (rough estimate)
Density 
1.0083 (rough estimate)
refractive index 
1.4500 (estimate)
solubility 
Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).
pka
13.12±0.40(Predicted)
form 
neat
color 
Crystals from MeOH
Merck 
14,5629
CAS DataBase Reference
52-76-6
EPA Substance Registry System
Lynestrenol (52-76-6)
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Safety Information

RTECS 
RC8964300
HS Code 
2937230000
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Lynestrenol Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

Progestogen;Antioestrogen

brand name

Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.

World Health Organization (WHO)

Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Safety Profile

An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge

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J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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TCI (Shanghai) Development Co., Ltd.
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Energy Chemical
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021-58432009
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
Email:
sales@chemreagents.com
LGM Pharma
Tel:
1-(800)-881-8210
Email:
inquiries@lgmpharma.com
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