ChemicalBook >  Product Catalog >  API >  Circulatory system drugs >  Lipid regulating drugs >  Acipimox

Acipimox

Basic information Description References Safety Related Supplier

Acipimox Basic information

Product Name:
Acipimox
CAS:
51037-30-0
MF:
C6H6N2O3
MW:
154.12
EINECS:
256-928-3
Mol File:
51037-30-0.mol
More
Less

Acipimox Chemical Properties

Melting point:
177-180 °C
Boiling point:
539.0±45.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.80±0.10(Predicted)
Merck 
14,111
InChIKey
DJQOOSBJCLSSEY-UHFFFAOYSA-N
CAS DataBase Reference
51037-30-0(CAS DataBase Reference)
EPA Substance Registry System
Pyrazinecarboxylic acid, 5-methyl-, 4-oxide (51037-30-0)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
RTECS 
UQ2453000
Toxicity
LD50 orally in mice: 3500 mg/kg (Ambrogi)
More
Less

Acipimox Usage And Synthesis

Description

Acipimox is a potent long-acting antilipolytic nicotinic acid (NA) analog. Like nicotinic acid, acipimox lowers lipids effectively, but unlike nicotinic acid, acipimox is longer acting and therefore much less prone to produce free fatty acid rebounding.
Acipimox is recommended as a lipid-lowering agent to treat hyperlipidemia in patients with noninsulin dependent diabetes mellitus.

References

[1] Ana T.M.G. Santomauro, Guenther Boden, Maria E.R. Silva, Dalva M. Rocha, Rosa F. Santos, Mileni J.M. Ursich, Paula G. Strassmann and Bernardo L. Wajchenberg, Overnight Lowering of Free Fatty Acids With Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects, Diabetes, 1999, vol. 48, 1836-1841
[2] K. C. Shih, C. F. Kwok, C. M. Hwu, L. C. Hsiao, S. H. Li, Y. F. Liu, L. T. Ho, Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control, Diabetes Research and Clinical Practice, 1997, vol. 36, 113-119

Description

Acipimox is a hypolipidemic agent related to nicotinic acid with pronounced, longlasting antilipolytic activity. In addition to its lipid lowering activity, it produces a beneficial elevation of the anti-atherogenic high density lipoprotein subfraction, HDL2.

Chemical Properties

Yellow Solid

Originator

Erbamont (Italy)

Uses

Antilipemic.

brand name

OLBETAM

Biological Activity

Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.

Acipimox Preparation Products And Raw materials

Raw materials

More
Less

AcipimoxSupplierMore

J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Capot Chemical Co., Ltd
Tel:
+86 (0) 571 85 58 67 18
Email:
sales@capotchem.com
BePharm Ltd
Tel:
4001-647-117; 021-61629020
Email:
product@bidepharmatech.com
Basic information Description References Safety Related Supplier