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Biphenyl Basic information

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Biphenyl Chemical Properties

Melting point:
68-70 °C(lit.)
Boiling point:
255 °C(lit.)
vapor density 
5.31 (vs air)
vapor pressure 
9.46 mm Hg ( 115 °C)
refractive index 
Flash point:
113 °C
storage temp. 
Soluble in alcohol and ether
Crystalline Powder, Crystals or Flakes
Specific Gravity
White to faint yellow
explosive limit
0.6%, 111°F
Water Solubility 
JECFA Number
Henry's Law Constant
2.92 at 25 °C (air stripping-GC, Destaillats and Charles, 2002)
Exposure limits
NIOSH REL: TWA 0.2 ppm, IDLH 100 mg/m3; OSHA PEL: TWA 0.2 ppm; ACGIH TLV: TWA 0.2 ppm.
Stable. Combustible. Incompatible with strong oxidising agents.
CAS DataBase Reference
92-52-4(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Biphenyl (92-52-4)

Safety Information

Hazard Codes 
Risk Statements 
Safety Statements 
UN 3077 9/PG 3
WGK Germany 
Autoignition Temperature
570 °C
HS Code 
Hazardous Substances Data
92-52-4(Hazardous Substances Data)
LD50 orally in rats: 3280 mg/kg (Deichmann)



Biphenyl Usage And Synthesis

Organic Chemicals

Biphenyl is also called phenyl benzene, it is formed by two connected phenyl compounds, is white or colorless to light yellow crystal plate, industrial products is slightly yellow with special fragrance. The melting temperature is 69.2 ℃, boiling point is 69.2 ℃. Insoluble in water, but soluble in organic solvents. Commonly used for organic synthesis precursor, is one of the key components of the organic high temperature heating medium. Its derivatives include benzidine, diphenyl ether, eight bromine diphenyl ether, polychlorinated biphenyls, etc. Natural biphenyl exists in coal tar, crude oil and natural gas, the mass fraction is 0.20% to 0.20% in coal tar, current preparation methods of biphenyl include coal tar extraction and chemical synthesis. The chemical bond in the middle of biphenyls can rotate freely, but if there were bulky groups in the four orthos, restricts rotation and would produce resistance isomer. This type of compounds (such as BINAP) can be used as a chiral ligands. Replace the PCB by Suzuki reaction and Ullmann coupling reactions. PCB is a kind of important organic raw materials, widely used in medicine, pesticides, dyes, liquid crystal materials, etc. Can be used in the synthesis of plasticizer, preservatives, can also be used to make fuel, engineering plastic and high energy fuel.
The above information is edited by the chemicalbook of Duan Yalan.

Content Analysis

Accurate take a sample of about 100 mg, dissolves in methanol to the capacity of 1000 ml, take 10 ml of the solution, add methanol to 200 ml, as a liquid sample. With methanol as the controlled liquid, with 1 cm long l liquid layer, determine the absorbance at 248 nm wavelength. A, press type: PCB content.
Content (%) = 20 x 10000 A/1118 x/sample (mg) by 100%


ADI 0~0.05 mg/kg (under some conditions 0.05~0.25 mg/kg FAO/WHO, 2001).
LD50 3.28~5.04 g/kg (mice, through the mouth).

Limited use

FAO/WHO, the United States and Canada regulations, its residual ≤110 mg/kg or less; Japan, France, Germany, the Netherlands, rules ≤70 mg/kg or less.

Chemical property

White or slightly yellow scaly crystal, has a unique fragrance. Insoluble in water, acid and alkali, soluble in alcohol, ether, benzene and other organic solvents.


It is the raw material of engineering plastic polysulfone, for making cross-linked with biphenyl, five PCB, used as a heat transfer medium, preservative, etc.
Used as the standard substance for chromatographic analysis.
Used for fresh citrus fruits such as grapefruit, orange, lemon skin mouldproof.
Commonly put the paper macerated of this product in the top and bottom of container, biphenyl sublimation in the storage and transportation process, adsorption on the skin of fruit, has mouldproof effect.
PCB with high thermal stability and low vapor pressure, long often alone or with diphenyl ether and blend to used as heating medium. Component of biphenyl and terphenyl (including PCB13%, terphenyl61%) can effectively absorb radiation, can be used as a heating medium for nuclear power plant. And three biphenyl ([91-94-4]) is the byproduct of benzene pyrolysis to produce PCB, according to the different reaction conditions, the proportion of the reaction product of biphenyl and terphenyl within a certain range of change, in general, PCB: terphenyl = 7-8. PCB is used as a carrier, and its derivatives of ethyl biphenyl, diethyl biphenyl and triethyl biphenyl senior can be used as solvents, used in pressure sensitive dye solvent of carbon paper.

Production Method

High temperature coal tar contains about 3.0% biphenyl, can be recycled from wash oil fractions. In 1926, the Dow chemical company started to produce PCB via benzene pyrolysis. Another source of PCB is by-product of toluene pyrolysis to produce alkyl benzene. With the development of the process, the by-product of biphenyl gradually become the main source of PCB. In the laboratory, the aniline diazotization, the diazonium salt in benzene, then add the mixture slowly to sodium hydroxide solution, mixing reaction, temperature rose gradually from 5 ℃ below to 30-35 ℃, generate PCB reaction after 8 h.


Flammable liquids

Toxicity grading


Acute toxicity

Oral-LD50 in rats: 2140 mg/kg. Oral LD50 in mice: 1900 mg/kg

Stimulus data

Eye-rabbit 100 mg light; Severe skin-rabbit 500 mg/24 hours

Explosive hazardous characteristics

Mixed with air explosive; And the oxidizing reaction

Flammability hazard characteristics

In open flame, high temperature, strong oxidizer flammable; Combustion emissions to stimulate the smoke; Small doses of nausea, vomiting, stomach discomfort, paralysis.

Storage Characteristics

Packaging complete, light light; Warehouse ventilation, away from open flame, high temperature, and antioxidant.

Extinguishing agent

CO2, dry powder, fog water

Occupational standards

TWA 0.2 PPM (1 mg/m3); STEL 0.6 parts per million (3 mg/m3)


Biphenyl, also called diphenyl, consists of two benzene rings joined by a single bond. It exists as colorless to yellowish crystals, has a distinctive odor, and occurs naturally in oil, natural gas, and coal tar.

Chemical Properties

Biphenyl has a pungent odor, reminiscent of rose on dilution.

Chemical Properties

white crystals

Chemical Properties

1,1’-Biphenyl is a clear colorless liquid with a pleasant odor and stable organic compound. It is combustible at high temperatures, producing carbon dioxide and water when combustion is complete. Partial combustion produces carbon monoxide, smoke, soot, and low molecular weight hydrocarbons. It is used extensively in the production of heat-transfer fl uids, for example, as an intermediate for polychlorinated biphenyls, and dye carriers for textile dyeing. It is also used as a mold retardant in citrus fruit wrappers, in the formation of plastics, optical brighteners, and hydraulic fl ui

Chemical Properties

Biphenyl is a combustible, white flakes or crystalline solid. Pleasant, characteristic odor.

Physical properties

White scales with a pleasant but peculiar odor. Odor threshold concentration is 0.83 ppb (quoted, Amoore and Hautala, 1983).


Reported found in coal tar, bilberry, carrots, peas, potato, bell pepper, rum, cocoa, tomato, coffee, roasted peanuts, olive (Olea europae), buckwheat and tamarind (Tamarindus indica L).


Biphenyl is used as an antifungal agent to preserve citrus fruit, in citrus wrappers to retard mold growth, in heat transfer fluids, in dye carriers for textiles and copying paper, as a solvent in pharmaceutical production, in optical brighteners, and as an intermediate for the production of a wide range of organic compounds.


Biphenyl is used to prevent fungal attack on stored citrus fruit. It is impregnated into fruit wraps.


As heat transfer agent; fungistat for oranges (applied to inside of shipping container or wrappers); in organic syntheses.


Fungistat for oranges; plant disease control.


ChEBI: A benzenoid aromatic compound that consists of two benzene rings connected by a single covalent bond. Biphenyl occurs naturally in coal tar, crude oil, and natural gas. Formerly used as a fungicide for citrus crops.


An organic compound having a structure in which two phenyl groups are joined by a C–C bond.


By thermal dehydrogenation of benzene.

Aroma threshold values

Detection: 0.5 ppb

General Description

A clear colorless liquid with a pleasant odor. Flash point 180°F. Insoluble in water. Vapors are heavier than air. Used to manufacture other chemicals and as a fungicide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Biphenyl is incompatible with oxidizers.

Health Hazard

CALL FOR MEDICAL AID. VAPOR, MIST OR DUST: Irritating to eyes, nose, throat and skin. Flush affected area with plenty of water. IF IN EYES, hold eyelids open and flush with plenty of water. SOLID OR LIQUID: Irritating to skin and eyes, nose and throat. Remove contaminated clothing and shoes. Flush affected areas with plenty water. IF IN EYES, hold eyelids open and flush with plenty of water. If swallowed, do not induce vomiting. Harmful if inhaled or swallowed. Causes irritation to eyes, skin and mucous membrane and upper respiratory tract. Causes central nervous system depression, paralysis and convulsion in animals. May cause headache, diffuse gastrointestinal pain, nausea, indigestion, numbness and aching of limbs, and general fatigue. Liver function test may show abnormalities. Chronic exposure is mostly characterized by central nervous system symptoms, fatigue, headache, tremor, insomnia, sensory impairment, and mood changes. Such symptoms are rare however.

Health Hazard

Exposures to 1,1’-biphenyl cause acute effects with symptoms that include, but are not limited to, polyuria, accelerated breathing, lacrimation, anorexia, weight loss, muscular weakness, coma, fatty liver cell degeneration, and severe nephrotic lesions. Exposure to biphenyl fumes for short periods of time causes nausea, vomiting, irritation of the eyes and respiratory tract, and bronchitis. Breathing small amounts of 1,1’-biphenyl over long periods of time causes damage to the liver and the nervous system of exposed workers. Breathing the mists, vapors, or fumes may irritate the nose, throat, and lungs. Depending on the concentration and duration of exposure, the symptoms include, but are not limited to, sore throat, coughing, labored breathing, sneezing, a burning sensation, and the effects of CNS depression. Symptoms may include headache, excitation, euphoria, dizziness, incoordination, drowsiness, light-headedness, blurred vision, fatigue, tremors, convulsions, loss of consciousness, coma, respiratory arrest, and death, depending on the concentration and duration of exposure

Fire Hazard

Combustible. Emits toxic fumes under fire conditions.

Potential Exposure

Biphenyl is a fungicide (pesticide). It is also used as a heat transfer agent, dye carrier, and as an intermediate in organic synthesis.


Present in coal tar at a concentration of 2.72 mg/g (Lao et al., 1975). Detected in woodpreserving creosotes at a concentration of 2.1 wt % (Nestler, 1974). Typical concentration of biphenyl in a heavy pyrolysis oil is 2.3 wt % (Chevron Phillips, May 2003).

Environmental Fate

Biological. Reported biodegradation products include 2,3-dihydro-2,3-dihydroxybi phenyl, 2,3-dihydroxybiphenyl, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate, 2-hydroxy- 3-phenyl-6-oxohexa-2,4-dienoate, 2-oxopenta-4-enoate, phenylpyruvic acid (Verschueren, 1983), 2-hydroxybiphenyl, 4-hydroxybiphenyl and 4,4′-hydroxybiphenyl (Smith and Rosazza, 1974). Under aerobic conditions, Beijerinckia sp. degraded biphenyl to cis-2,3- dihydro-2,3-dihydroxybiphenyl. In addition, Oscillatoria sp. and Pseudomonas putida degraded biphenyl to 4-hydroxybiphenyl and benzoic acid, respectively (Kobayashi and Rittman, 1982). The microbe Candida lipolytica degraded biphenyl into the following products: 2-, 3- and 4-hydroxybiphenyl, 4,4′-dihydroxybiphenyl and 3-methoxy-4-hydrox ybiphenyl (Cerniglia and Crow, 1981). With the exception of 3-methoxy-4-hydroxybiphe nyl, these products were also identified as metabolites by Cunninghanella elegans (Dodge et al., 1979). In activated sludge, 15.2% mineralized to carbon dioxide after 5 days (Freitag et al., 1985).
Photolytic. A carbon dioxide yield of 9.5% was achieved when biphenyl adsorbed on silica gel was irradiated with light (λ >290 nm) for 17 hours. Irradiation of biphenyl (λ >300 nm) in the presence of nitrogen monoxide resulted in the formation of
Chemical/Physical. The aqueous chlorination of biphenyl at 40°C over a pH range of 6.2 to 9.0 yielded o-chlorobiphenyl and m-chlorobiphenyl (Snider and Alley, 1979). In an acidic aqueous solution (pH 4.5) containing bromide ions and a chlorinatin
Biphenyl will not hydrolyze since it has no hydrolyzable functional group.

Metabolic pathway

Biphenyl is a stable compound. It has a restricted use as a fungistat applied to citrus packing material. This has generated studies on its toxicity and metabolism in mammals and residue studies in stored fruit. Only limited information on its environmental fate has been published.


1,1’-Biphenyl should be kept stored in tightly closed containers in a cool, dry, isolated, and properly ventilated area, away from heat, sources of ignition, incompatibles, and contact with strong oxidizers.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.

Purification Methods

Crystallise biphenyl from EtOH, MeOH, aqueous MeOH, pet ether (b 40-60o) or glacial acetic acid. Free it from polar impurities by passage through an alumina column in *benzene, followed by evaporation. The residue has been purified by distillation in a vacuum and by zone refining. Treatment with maleic anhydride removes anthracene-like impurities. It has been recrystallised from EtOH followed by repeated vacuum sublimation and passage through a zone refiner. [Taliani & Bree J Phys Chem 88 2351 1984, Beilstein 5 H 576, 5 I 271, 5 II 479, 5 III 1726, 5 IV 1807.]


Biphenyl is not subject to hydrolysis.


Mist may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.


Occupational workers should be careful during use and chemical management because the fi nely dispersed particles of 1,1’-biphenyl form explosive mixtures in air



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Basic information Organic Chemicals Content Analysis Toxicity Limited use Chemical property Uses Production Method Category Toxicity grading Acute toxicity Stimulus data Explosive hazardous characteristics Flammability hazard characteristics Storage Characteristics Extinguishing agent Occupational standards Safety Related Supplier