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N-Methylaniline

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N-Methylaniline Basic information

Product Name:
N-Methylaniline
CAS:
100-61-8
MF:
C7H9N
MW:
107.15
EINECS:
202-870-9
Mol File:
100-61-8.mol
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N-Methylaniline Chemical Properties

Melting point:
−57 °C(lit.)
Boiling point:
196 °C(lit.)
Density 
0.989 g/mL at 25 °C(lit.)
vapor pressure 
0.5 hPa (20 °C)
refractive index 
n20/D 1.571(lit.)
Flash point:
174 °F
storage temp. 
Store below +30°C.
solubility 
water: slightly soluble30g/L
form 
Liquid
pka
4.84(at 25℃)
color 
Clear yellow to brown
Odor
Moderate aniline-type.
PH
7.6 (1g/l, H2O, 20℃)
Water Solubility 
30 g/L
Sensitive 
Air Sensitive
Merck 
14,6019
BRN 
741982
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.19 at 25 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits
NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 2 ppm (9 mg/m3); ACGIH TLV: TWA 0.5 ppm (adopted).
Stability:
Stability Combustible. Incompatible with strong oxidizing agents. Discolours upon exposure to air.
InChIKey
AFBPFSWMIHJQDM-UHFFFAOYSA-N
CAS DataBase Reference
100-61-8(CAS DataBase Reference)
NIST Chemistry Reference
Aniline, N-methyl-(100-61-8)
EPA Substance Registry System
N-Methylaniline (100-61-8)
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Safety Information

Hazard Codes 
T,N
Risk Statements 
23/24/25-33-50/53
Safety Statements 
28-36/37-45-60-61-28A
RIDADR 
UN 2294 6.1/PG 3
WGK Germany 
3
RTECS 
BY4550000
8
Autoignition Temperature
500 °C
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
Hazardous Substances Data
100-61-8(Hazardous Substances Data)
Toxicity
LD in rabbits (g/kg): 0.28 orally; in rabbits, cats (mg/kg): 24, 24 i.v. (Treon)

MSDS

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N-Methylaniline Usage And Synthesis

Chemical Properties

N-Methylaniline is a yellow to light brown oily liquid with a weak, ammonia-like odor. Turns reddishbrown if left standing. The odor threshold is 1.7 ppm

Physical properties

Colorless to yellow to pale brown liquid with a faint, ammonia-like odor. Odor threshold concentration is 1.7 ppm (quoted, Amoore and Hautala, 1983).

Uses

N-Methylaniline is used as a solvent and in organic synthesis.

Uses

Chemical syntheses

Uses

Organic synthesis, solvent, acid acceptor.

Definition

ChEBI: A methylaniline that is aniline carrying a methyl substituent at the nitrogen atom.

Hazard

Toxic by ingestion, inhalation, and skin absorption. Methemoglobinemia and central nervous system impairment.

Health Hazard

Recommended Personal Protective Equipment: Approved respirator; rubber gloves; splash proof goggles; Symptoms Following Exposure: Inhalation causes dizziness and headache. Ingestion causes bluish discoloration (cyanosis) of lips, ear lobes, and fingernail beds. Liquid irritates eyes. Absorption through skin produces same symptoms as for ingestion; General Treatment for Exposure: INHALATION: remove victim to fresh air and call a physician at once; administer oxygen until physician arrives. INGESTION: give large amount of water; get medical attention at once. EYES or SKIN: flush with plenty of water for at least 15 min.; if cyanosis is present, shower with soap and warm water, with special attention to scalp and finger nails; remove any contaminated clothing; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Inhalation Limits: Data not available; Toxicity by Ingestion: Data not available; Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Data not available; Liquid or Solid Irritant Characteristics: Data not available; Odor Threshold: Data not available.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastic; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

The material is used as an intermediate in organic synthesis, as a solvent and as an acid acceptor

Carcinogenicity

N-methyl aniline (1.95 g/kg of food) given together with sodium nitrite (1.0 g/l of drinking water) to Swiss mice resulted in a 17% incidence of lung adenomas and a 14% incidence of malignant lymphomas; there were no carcinogenic effects in animals treated with Nmethyl aniline alone, suggesting that in vivo nitrosation is necessary for forming carcinogenic nitrosamines.
In bacterial mutagenicity assays N-methyl aniline was negative with or without metabolic activation.

Environmental Fate

Soil. Reacts slowly with humic acids or humates forming quinoidal structures (Parris, 1980).

Shipping

UN2294 N-Methylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Dry it with KOH pellets and fractionally distil it under vacuum. Acetylate, and the acetyl derivative is recrystallised to constant melting point (m 101-102o), then hydrolysed with aqueous HCl and distilled from zinc dust under reduced pressure. [Hammond & Parks J Am Chem Soc 77 340 1955, Beilstein 12 IV 241.]

Waste Disposal

Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.

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Changzhou Baolong Chemical Industrial Co.,Ltd Gold
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