N-Methylaniline Chemical Properties
- Melting point:
- −57 °C(lit.)
- Boiling point:
- 196 °C(lit.)
- 0.989 g/mL at 25 °C(lit.)
- vapor pressure
- 0.5 hPa (20 °C)
- refractive index
- Flash point:
- 174 °F
- storage temp.
- Store below +30°C.
- water: slightly soluble30g/L
- 4.84(at 25℃)
- Clear yellow to brown
- Moderate aniline-type.
- 7.6 (1g/l, H2O, 20℃)
- Water Solubility
- 30 g/L
- Air Sensitive
- Henry's Law Constant
- (x 10-5 atm?m3/mol): 1.19 at 25 °C (approximate - calculated from water solubility and vapor pressure)
- Exposure limits
- NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 2 ppm (9 mg/m3); ACGIH TLV: TWA 0.5 ppm (adopted).
- Stability Combustible. Incompatible with strong oxidizing agents. Discolours upon exposure to air.
- CAS DataBase Reference
- 100-61-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Aniline, N-methyl-(100-61-8)
- EPA Substance Registry System
- N-Methylaniline (100-61-8)
- Hazard Codes
- Risk Statements
- Safety Statements
- UN 2294 6.1/PG 3
- WGK Germany
- Autoignition Temperature
- 500 °C
- HS Code
- Hazardous Substances Data
- 100-61-8(Hazardous Substances Data)
- LD in rabbits (g/kg): 0.28 orally; in rabbits, cats (mg/kg): 24, 24 i.v. (Treon)
N-Methylaniline Usage And Synthesis
N-Methylaniline is a yellow to light brown oily liquid with a weak, ammonia-like odor. Turns reddishbrown if left standing. The odor threshold is 1.7 ppm
Colorless to yellow to pale brown liquid with a faint, ammonia-like odor. Odor threshold concentration is 1.7 ppm (quoted, Amoore and Hautala, 1983).
N-Methylaniline is used as a solvent and in organic synthesis.
Organic synthesis, solvent, acid acceptor.
ChEBI: A methylaniline that is aniline carrying a methyl substituent at the nitrogen atom.
Toxic by ingestion, inhalation, and skin absorption. Methemoglobinemia and central nervous system impairment.
Recommended Personal Protective Equipment: Approved respirator; rubber gloves; splash proof goggles; Symptoms Following Exposure: Inhalation causes dizziness and headache. Ingestion causes bluish discoloration (cyanosis) of lips, ear lobes, and fingernail beds. Liquid irritates eyes. Absorption through skin produces same symptoms as for ingestion; General Treatment for Exposure: INHALATION: remove victim to fresh air and call a physician at once; administer oxygen until physician arrives. INGESTION: give large amount of water; get medical attention at once. EYES or SKIN: flush with plenty of water for at least 15 min.; if cyanosis is present, shower with soap and warm water, with special attention to scalp and finger nails; remove any contaminated clothing; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Inhalation Limits: Data not available; Toxicity by Ingestion: Data not available; Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Data not available; Liquid or Solid Irritant Characteristics: Data not available; Odor Threshold: Data not available.
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastic; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
The material is used as an intermediate in organic synthesis, as a solvent and as an acid acceptor
N-methyl aniline (1.95 g/kg of food) given
together with sodium nitrite (1.0 g/l of drinking
water) to Swiss mice resulted in a 17% incidence
of lung adenomas and a 14% incidence
of malignant lymphomas; there were no carcinogenic
effects in animals treated with Nmethyl
aniline alone, suggesting that in vivo
nitrosation is necessary for forming carcinogenic
In bacterial mutagenicity assays N-methyl aniline was negative with or without metabolic activation.
Soil. Reacts slowly with humic acids or humates forming quinoidal structures (Parris, 1980).
UN2294 N-Methylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Dry it with KOH pellets and fractionally distil it under vacuum. Acetylate, and the acetyl derivative is recrystallised to constant melting point (m 101-102o), then hydrolysed with aqueous HCl and distilled from zinc dust under reduced pressure. [Hammond & Parks J Am Chem Soc 77 340 1955, Beilstein 12 IV 241.]
Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.
N-Methylaniline Preparation Products And Raw materials
- Diphenylcarbamyl chloride
- N-METHYL-N-PHENYLCARBAMOYL CHLORIDE
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