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L-Isoleucine

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L-Isoleucine Basic information

Product Name:
L-Isoleucine
CAS:
73-32-5
MF:
C6H13NO2
MW:
131.17
EINECS:
200-798-2
Mol File:
73-32-5.mol
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L-Isoleucine Chemical Properties

Melting point:
288 °C (dec.)(lit.)
alpha 
41 º (c=4, 6N HCl)
Boiling point:
225.8±23.0 °C(Predicted)
Density 
1.2930 (estimate)
FEMA 
4675 | L-ISOLEUCINE
refractive index 
40.5 ° (C=4, 6mol/L HCl)
Flash point:
168-170°C
storage temp. 
Store at RT.
solubility 
1 M HCl: 50 mg/mL
pka
2.32, 9.76(at 25℃)
form 
powder
color 
White to Off-white
PH
5.5-6.5 (40g/l, H2O, 20℃)
optical activity
[α]20/D +41.0±1°, c = 5% in 6 M HCl
Water Solubility 
41.2 g/L (50 ºC)
λmax
λ: 260 nm Amax: 0.07
λ: 280 nm Amax: 0.05
Sublimation 
168-170 ºC
Merck 
14,5179
JECFA Number
2118
BRN 
1721792
InChIKey
AGPKZVBTJJNPAG-WHFBIAKZSA-N
CAS DataBase Reference
73-32-5(CAS DataBase Reference)
NIST Chemistry Reference
Isoleucine(73-32-5)
EPA Substance Registry System
L-Isoleucine (73-32-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
24/25-36-22
WGK Germany 
3
RTECS 
NR4705000
TSCA 
Yes
HS Code 
29224995
Toxicity
LD50 intraperitoneal in rat: 6822mg/kg

MSDS

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L-Isoleucine Usage And Synthesis

Description

Crystalline leaflets or a white, crystalline powder having a bitter taste. It is soluble in 25 parts of water, slightly soluble in hot alcohol, and soluble in diluted mineral acids and in alkaline solutions. It sublimes at between 168°C and 170°C, and melts with decomposition at about 284°C. The pH of a 1 in 100 solution is between 5.5 and 7.0.
Absolute: The absolute is prepared by alcoholic extraction of the concrete in approximately 55 to 60% yields. The absolute consists of a semisolid, olive-green mass with a characteristic ambergris odor.
Resinoid and Resin Absolute: The resinoid consists of the hydro carbon extract of the crude resin. The resin absolute consists of the alcoholic extract of the crude labdanum resin. Since this prod uct is a semisolid, nonpourable mass, a high-boiling, odorless solvent may be added prior to evaporation of the alcohol to prepare a pourable liquid.

Chemical Properties

White crystalline powder

Uses

L-Isoleucine, also known as Isoleucine, is an amino acid that is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
L-Isoleucine is one of the essential amino acids that cannot be made by the body and is known for its ability to help endurance and assist in the repair and rebuilding of muscle. This amino acid is important to body builders as it helps boost energy and helps the body recover from training.
L-Isoleucine is also classified as a branched-chain amino acid (BCAA). There are three branched-chain amino acids in the body, with the others being L-Valine, and L-Leucine, and all of them help promote muscle recovery after exercise. Isoleucine is actually broken down for energy within the muscle tissue.

Definition

ChEBI: The L-enantiomer of isoleucine.

Purification Methods

Crystallise L-isoleucine from H2O by addition of 4 volumes of EtOH or from aqueous MeOH. It sublimes at 170-181o/0.3mm with 99.7% recovery, unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 1 p 183-191, Vol 3 pp 2043-2073 1961, Huffman & Ingersoll J Am Chem Soc 73 3366 1951, Beilstein 4 IV 2775.]

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