Bifemelane
hydrochloride,ABATRA Technology
Co., Ltd.
ChEBI: N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine is a diarylmethane.
N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine was prepared from 2-
(5-bromopentyloxy)diphenylmethane and of methylamine in ethanol is at
50°C in a sealed tube (heating for 3 hours). Ethanol and excess methylamine
are distilled in vacuo, 2 N NaOH aqueous solution is added, and the reaction
product is extracted with ether. Dry hydrogen chloride gas is passed into the
ether solution, and the precipitate collected by filtration. Recrystallization from
ethanol-ether gives N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine
hydrochloride, m.p. 87.5-89.5°C.
Antidepressant, Antiulcer, Nootropic
Antidepressant MAO inhibitor. Reverses catalepsy induced by tetrabenazine in mice and increases locomotor activity in MPTP-treated marmosets.
