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Kanamycin sulfate

Basic information Description Reference Safety Related Supplier

Kanamycin sulfate Basic information

Product Name:
Kanamycin sulfate
CAS:
25389-94-0
MF:
C18H38N4O15S
MW:
582.58
EINECS:
246-933-9
Mol File:
25389-94-0.mol
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Kanamycin sulfate Chemical Properties

Melting point:
250°C
alpha 
+112~+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)
Density 
1.3619 (rough estimate)
refractive index 
117.5 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
form 
powder
color 
white to off-white
PH Range
6.5 - 8.5 (1% solution)
Water Solubility 
Soluble in water at 10mg/ml
Merck 
14,5281
InChIKey
OOYGSFOGFJDDHP-KMCOLRRFSA-N
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Safety Information

Hazard Codes 
T
Risk Statements 
61
Safety Statements 
22-24/25-45-53
WGK Germany 
3
RTECS 
NZ3225030
HS Code 
29419020
Toxicity
LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)

MSDS

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Kanamycin sulfate Usage And Synthesis

Description

It has been well known as desirable antibiotics, which shows an obvious curative effect on serious infections caused by gram-negative bacteria such as Escherichia coil, Klebsiella, Proteus, Pneumonia, Enterobacter aerogenes and Shigella. Clinically, this substance is mainly used for infections caused by sensitive bacteria including pulmonary infection, urinary tract infection, biliary tract infection, sepsis, and abdominal cavity infection. For example, the effective antibacterial activity of kanamycin sulfate has been demonstrated by the treatment of acute gonorrheal urethritis in men, showing that a single parenterally administered dose of 2 mg of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis.1 Moreover, kanamycin sulfate was found to be a valuable drug in the treatment of serious infections in infants and children through an analysis of 140 cases treated during a two-year period.2

Reference

  1. JE Fischnaller; AH Pedersen; AR Ronald; P Bonin; Tronca, E., Kanamycin sulfate in the treatment of acute gonorrheal urethritis in men. The Journal of the American Medical Association 1968, 203, 909-912.
  2. MD Yow; Tengg, N., The use of kanamycin sulfate as a therapeutic agent for infants and children. An analysis of 140 cases treated during a two-year period. Journal of Pediatrics 1961, 58, 538-547.

Chemical Properties

Off-white powder

Uses

Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

Definition

A broadspectrum antibiotic.

brand name

Klebcil (King).

Kanamycin sulfate Preparation Products And Raw materials

Raw materials

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Kanamycin sulfateSupplierMore

Shanghai Boyle Chemical Co., Ltd.
Tel:
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Email:
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
INTATRADE GmbH
Tel:
+49 3493/605464
Email:
sales@intatrade.de
TAIYUAN RHF CO.,LTD.
Tel:
+86 351 7031519
Email:
sales@RHFChem.com
Basic information Description Reference Safety Related Supplier