Basic information Treatment of cancer and rheumatoid arthritis History of discovery Immunosuppressants Pharmacological effects Pharmacokinetics Clinical application Dosage Adverse reactions and precautions Drug Interactions Chemical Properties Production method Safety Related Supplier
Methotrexate Structure

Methotrexate

Chemical Properties

Melting point 195°C
Boiling point 561.26°C (rough estimate)
alpha  +17~+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Density  1.4080 (rough estimate)
refractive index  1.6910 (estimate)
Flash point 11℃
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: insoluble
form  powder
pka pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
Water Solubility  Insoluble. <0.1 g/100 mL at 19 ºC
Sensitive  Light Sensitive & Hygroscopic
Merck  14,5985
BRN  70669
BCS Class 3
Stability Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
InChIKey FBOZXECLQNJBKD-ZDUSSCGKSA-N
CAS DataBase Reference 59-05-2(CAS DataBase Reference)
NIST Chemistry Reference Methotrexate(59-05-2)
IARC 3 (Vol. 26, Sup 7) 1987
EPA Substance Registry System Methotrexate (59-05-2)

Safety Information

Hazard Codes  T,F
Risk Statements  61-25-36/38-46-39/23/24/25-23/24/25-11
Safety Statements  53-26-36/37-45-36/37/39-36-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  MA1225000
3-8-10
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335995
Hazardous Substances Data 59-05-2(Hazardous Substances Data)
Toxicity LD50 oral in rat: 135mg/kg

MSDS

Usage And Synthesis

Methotrexate Supplier

Methotrexate manufacturers