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ergotamine

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ergotamine Basic information

Product Name:
ergotamine
CAS:
113-15-5
MF:
C33H35N5O5
MW:
581.66
EINECS:
204-023-9
Mol File:
113-15-5.mol
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ergotamine Chemical Properties

Melting point:
241-249℃
alpha 
D20 -160° (chloroform)
Boiling point:
651.33°C (rough estimate)
Density 
1.0998 (rough estimate)
refractive index 
1.7500 (estimate)
pka
pKa 6.40±0.09(H2O t=24.0) (Uncertain)
CAS DataBase Reference
113-15-5
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Safety Information

RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in mice, rats, rabbits (mg/kg): 62, 80, 3 i.v.; in cats: 11 s.c. (Rothlin)
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ergotamine Usage And Synthesis

Uses

Analgesic (specific in migraine).

Definition

ChEBI: A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.

brand name

Ergomar (Harvest);Ergostat (Parke-Davis); Wigrettes (Organon).

Purification Methods

Crystallise it from *benzene, then dry it by prolonged heating in high vacuum. It is very hygroscopic. [Beilstein 25 III/IV 964.]

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