ergotamine Chemical Properties

Melting point:

241-249℃

alpha 

D20 -160° (chloroform)

Boiling point:

651.33°C (rough estimate)

Density 

1.0998 (rough estimate)

refractive index 

1.7500 (estimate)

pka

pKa 6.40±0.09(H2O t=24.0) (Uncertain)

CAS DataBase Reference

113-15-5

Safety Information

RIDADR 

1544

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 in mice, rats, rabbits (mg/kg): 62, 80, 3 i.v.; in cats: 11 s.c. (Rothlin)

ergotamine Usage And Synthesis

Uses

Analgesic (specific in migraine).

Definition

ChEBI: A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.

brand name

Ergomar (Harvest);Ergostat (Parke-Davis); Wigrettes (Organon).

Purification Methods

Crystallise it from *benzene, then dry it by prolonged heating in high vacuum. It is very hygroscopic. [Beilstein 25 III/IV 964.]

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