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Baicalin

Basic information Description References Safety Related Supplier

Baicalin Basic information

Product Name:
Baicalin
CAS:
21967-41-9
MF:
C21H18O11
MW:
446.36
EINECS:
606-866-1
Mol File:
21967-41-9.mol
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Baicalin Chemical Properties

Melting point:
231-233 °C(lit.)
alpha 
-85 º (c=1, DMSO)
Boiling point:
836.6±65.0 °C(Predicted)
Density 
1.737±0.06 g/cm3(Predicted)
form 
solid
pka
2.72±0.70(Predicted)
optical activity
[α]20/D 85°, c = 1 in DMSO
InChIKey
IKIIZLYTISPENI-ZFORQUDYSA-N
CAS DataBase Reference
21967-41-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
LZ5776910
HS Code 
29329990

MSDS

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Baicalin Usage And Synthesis

Description

Baicalin, the active compound of the Blue Skullcap, is a type of flavonoid.
Baicalin exhibits anti-inflammatory, anti-tumor, anti-angiogenic, anti-oxidant, anti-apoptotic, anti-viral, and antibacterial properties. It could be used for the treatment of autoimmune diseases and several cancers (hepatitis B virus (HBV)-infected liver cancer,  hepatic cancer, cervical cancer, etc.). It can be used to treat against dengue virus. It is used in preparation of the drug for treating and rescuing ricin poisoning. Due to its anti-apoptotic effect which can protect PC-12 cells from oxidative stress, baicalin can be used for reducing stress and helping to promote healthy sleep cycles.

References

[1] Ehsan Moghaddam, Boon-Teong Teoh, Sing-Sin Sam, Rafidah Lani, Pouya Hassandarvish, Zamri Chik, Andrew Yueh, Sazaly Abubakar, Keivan Zandi (2014) Baicalin, a metabolite of baicalein with antiviral activity against dengue virus, Scientific Reports, 4, 5452
[2] Yuan Zhang, Xing Li, Bogoljub Ciric, Cun-Gen Ma, Bruno Gran, Abdolmohamad Rostami, Guang-Xian Zhang (2015) Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway, Scientific Reports, 5, 17407
[3] Patent US 20160361334 A1: Application of baicalin in preparation of drug for treating ricin poisoning

Chemical Properties

Light yellow powder

Uses

diuretic, prolyl endopeptidase inhibitor, antineoplastic

Definition

ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of baicalein.

Enzyme inhibitor

This baicalein glucuronide (FW = 446.36 g/mol; CAS 21967-41-9), also known as 5,6-dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-b-D glucopyranose acid, is a flavone prodrug found in the Chinese medicinal herb Huang-chin (Scutellaria baicalensis) that is hydrolyzed to baicalein (See Baicalein). Baicalin is a slow, tight-binding inhibitor of Jack Bean urease, rapidly forming initial BA-urease complex (Ki = 3.9 × 10–3 M) that slowly isomerizes to the final complex (overall inhibition constant of Ki* = 0.15 × 10 μM. Inhibition can be reversed by dithiothreitol but not dilution of substrate. Baicalin also inhibits prolyl oligopeptidase, a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues and is associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders. (See Pramiracetam)

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BaicalinSupplierMore

Wuhan Yijia Biotechnology Co., Ltd Gold
Tel:
Email:
2013537414@qq.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
INTATRADE GmbH
Tel:
+49 3493/605464
Email:
sales@intatrade.de
future industrial shanghai co., ltd
Tel:
400-0066-400;021-60496031
Email:
sales@jonln.com;sales@jonln.com
Basic information Description References Safety Related Supplier