4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 性质
| 熔点 | 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2)) |
|---|---|
| 沸点 | 460.7±45.0 °C(Predicted) |
| 密度 | 1.250±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：50 mg/mL（154.64 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 15.41±0.50(Predicted) |
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 用途与合成方法
IC50: 11 nM (Gardos channel)
ICA-17043 is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC 50 of 50±6 nM. ICA-17043 blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion.
ICA-17043 (10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K + content without changes in Na + content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep.
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-50694 | 5 mg | 604 | ||
| 2024-01-25 | HY-50694 | 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 | 289656-45-7 | 10mg | 967 |
