基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MKT 077 价格(试剂级) 供应商
网站主页  化工产品目录 生物化工  生化试剂  激动剂抑制剂  MKT 077

MKT 077

MKT 077

中文名称:MKT 077
英文名称:MKT 077
CAS号:147366-41-4
分子式:C21H22ClN3OS2
分子量:432.00188
EINECS号:
Mol文件:147366-41-4.mol
MKT 077 结构式

MKT 077 性质

储存条件 2-8°C
溶解度 在水中的溶解度为10mg/mL,澄清
形态 粉末
颜色 橙色至红色

MKT 077 用途与合成方法

MKT-077 (FJ-776)是一种新合成的、具有高水溶性的复合份菁染料(rhodacyanine dye),在多种模型中具有显著的抗肿瘤活性。

HSP70

MKT-077 is a rhodacyanine dye and also a heat shock protein 70 (Hsp70) inhibitor which exhibits significant antitumor activity. MKT-077 treatment (0.1 to 10 µM dose ranges) for 48 hours can effectively decrease TT cell viability. MKT-077 treatment results in accumulation of cells in the G0/G1 phase in a dose-dependent manner, and also increases sub-G0/G1 phase population in TT cell culture in a dose-dependent manner. MKT-077 also downregulates cellular levels of the proliferation marker, Ki67, and the S-phase transcription factor, E2F-1, in TT and MZ-CRC-1 cells. Moreover, flow cytometry using different doses of MKT-077 reveales that TT cells can uptake and retain MKT-077 at significantly higher levels than MZ-CRC-1 cells. MKT-077 has EC 50 values of 1.4±0.2 and 2.2±0.2 μM against MDA-MB-231 and MCF7 breast cancer cells, respectivelyl.

Systemic administration of MKT-077 significantly delays the growth of TT xenografts in mice throughout the treatment. At the end of MKT-077 treatment, it is found that tumor weights are about two-times less in MKT-077-treated group than in control group. MKT-077 treatment also results in weight loss and general toxicity in animals. Results show that the succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls.

安全信息

WGK Germany3
RTECS号UU4023332
毒性LD50 intraperitoneal in mouse: 50mg/kg

MKT 077 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-15096 1 mg 419
2024-01-25 HY-15096 MKT 077 147366-41-4 5mg 1000

MKT 077供应商 更多

天津凯利奇生物科技有限公司
现货
联系电话: 15076683720
产品介绍:
英文名称:MKT-077
CAS:147366-41-4
纯度:>98%
包装信息:2g
备注:2g
库存量:2g
现货日期:2024/3/22 10:45:59
上海泰坦科技股份有限公司
联系电话:400-6009262 16621234537
产品介绍:
中文名称:1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[d]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物
英文名称:1-Ethyl-2-((Z)-((Z)-3-Ethyl-5-(3-mEthylbenzo[d]Thiazol-2(3H)-Ylidene)-4-oxoThiazolidin-2-Ylidene)mEthyl)Pyridin-1-Ium Chloride
CAS:147366-41-4
纯度:95%
包装信息:100mg;250mg;1g;5g
大连美仑生物技术有限公司
联系电话:0411-62910999 13889544652
产品介绍:
英文名称:MKT-077
CAS:147366-41-4
纯度:>98%,BR
包装信息:5MG
备注:MB0302
南京百鑫德诺生物科技有限公司
联系电话:025-58849295 18951903616;
产品介绍:
英文名称:MKT 077
CAS:147366-41-4
纯度:0.98
包装信息:1mg;5mg;10mg;25mg;50mg;100mg
备注:试剂
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话:021-61415566 800-8193336
产品介绍:
英文名称:MKT-077
CAS:147366-41-4
纯度:>=98% (HPLC)
包装信息:5mg, 25mg
备注:M5449