基本属性 生物活性靶点体外研究体内研究 用途与合成方法 昂曲托来 价格(试剂级) 上下游产品信息 供应商 相关产品

昂曲托来

昂曲托来

中文名称:昂曲托来
英文名称:Omtriptolide
CAS号:195883-06-8
分子式:C24H28O9
分子量:460.47
EINECS号:
Mol文件:195883-06-8.mol
昂曲托来 结构式

昂曲托来 性质

熔点 109-111 ºC
沸点 691.4±55.0 °C(Predicted)
密度 1.49
储存条件 Store at -20°C
溶解度 溶于二甲基亚砜
酸度系数(pKa) 4.36±0.17(Predicted)

昂曲托来 用途与合成方法

Omtriptolide (PG490-88) 是从中草药纯化的雷公藤内酯的水溶性衍生物前药。

ERK

Triptolide, a traditional Chinese medicine, has anti-inflammatory, antiproliferative, and proapoptotic properties.

In a mouse model of cisplatin-induced AKI, omtriptolide results in a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI. The protection of omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines. In a mouse heterotopic tracheal allograft model of obliterative airway disease, omtriptolide attenuates airway obliteration and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation. Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation).

昂曲托来 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-16363 昂曲托来 195883-06-8 1mg 1500
2024-01-25 HY-16363 昂曲托来 195883-06-8 5mg 4500

昂曲托来 上下游产品信息

下游产品

昂曲托来供应商 更多

ChemeGen 中国
联系电话: 18818260767
产品介绍:
中文名称:昂曲托来
英文名称:Omtriptolide
CAS:195883-06-8
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
成都超九八生物科技有限公司
联系电话:13348960310 13348960310
产品介绍:
中文名称:昂曲托来
英文名称:Omtriptolide
CAS:195883-06-8
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223
产品介绍:
中文名称:昂曲托来
英文名称:Omtriptolide
CAS:195883-06-8
纯度:98%
包装信息:1mg;5mg;10mg
苏州美石生物科技有限公司
联系电话: 1173954148q
产品介绍:
英文名称:195883-06-8
CAS:195883-06-8
纯度:99% HPLC
包装信息:1G;5G;10G;100G;1KG;
备注:医药级

"昂曲托来"相关产品信息