Acesulfame potassium Chemical Properties
- Melting point:
- 229-232°C (dec.)
- (solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
- storage temp.
- Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
- White crystalline solid
- odorless with sweet taste
- Water Solubility
- almost transparency
- CAS DataBase Reference
- 55589-62-3(CAS DataBase Reference)
- EPA Substance Registry System
- Acesulfame-potassium (55589-62-3)
Acesulfame potassium Usage And Synthesis
White to Off-White Solid
Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.
Acesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.
'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.
Potassium salt as sweetener for foods, cosmetics.
Acesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)-
one-2,2-dioxide. This sweetener was discovered in Germany and was
first approved by the FDA in 1988 for use as a nonnutritive sweetener.
The complex chemical name of this substance led to the creation of the
trademark common name, acesulfame-K, which is based on its following
relationships to acetocetic acid and sulfanic acid, and to its potassium
Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.
Acesulfame potassium is synthesized from acetoacetic acid tertbutyl
ester and fluorosulfonyl isocyanate. The resulting compound
is transformed to fluorosulfonyl acetoacetic acid amide, which is
then cyclized in the presence of potassium hydroxide to form the
oxathiazinone dioxide ring system. Because of the strong acidity of
this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.
The principal commercial process for acesulfame-K is depicted below: 图
Acesulfame potassium is used as an intense sweetening agent in
cosmetics, foods, beverage products, table-top sweeteners, vitamin
and pharmaceutical preparations, including powder mixes, tablets,
and liquid products. It is widely used as a sugar substitute in
compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.
When heated to decompositionemits toxic fumes of SOx.
Acesulfame potassium is widely used in beverages, cosmetics, foods,
and pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material. Pharmacokinetic
studies have shown that acesulfame potassium is not metabolized
and is rapidly excreted unchanged in the urine. Long-term feeding
studies in rats and dogs showed no evidence to suggest acesulfame
potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, oral): 6.9–8.0 g/kg
Acesulfame potassium possesses good stability. In the bulk form it
shows no sign of decomposition at ambient temperature over many
years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in
sweetness was observed over a period of approximately 2 years.
Stability at elevated temperatures is good, although some decomposition
was noted following storage at 408℃ for several months.
Sterilization and pasteurization do not affect the taste of acesulfame
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.
Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.
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