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Clopidogrel

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Clopidogrel Basic information

Product Name:
Clopidogrel
CAS:
113665-84-2
MF:
C15H14ClNO2S
MW:
307.8
EINECS:
601-269-2
Mol File:
113665-84-2.mol
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Clopidogrel Chemical Properties

alpha 
D20 +51.52° (c = 1.61 in methanol)
Boiling point:
423.7±45.0 °C(Predicted)
Density 
1.317±0.06 g/cm3(Predicted)
pka
4.56±0.20(Predicted)
CAS DataBase Reference
113665-84-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
Hazardous Substances Data
113665-84-2(Hazardous Substances Data)
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Clopidogrel Usage And Synthesis

Description

Clopidogrel was launched in the US as a potent inhibitor of platelet aggregation for the preventive management of secondary ischemic events, including MI, stroke and vascular deaths. Clopidogrel can be synthesized in 4 steps (including an optical resolution to the S active enantiomer) from 2-(2- ch1orophenyl)-glycine, the key step being the cyclization to thienopyridine with formaldehyde and acetic acid. Clopidogrel belongs to the original chemical class of Ticlopidine, but shows fewer side effects (in particular, bone-marrowsuppressing effects) at the dosage generally used. Like Ticlopidine, it is an Adenosine diphosphate (ADP) antagonist acting at the purinergic P2y receptor. In in vivo experiments with rabbits, Clopidogrel shows a maximal antiaggregant effect at 20mg/kg po, reducing adhesion of platelets to the vascular subendothelium ; moreover, it reduces myointimal thickening occuring after endothelial injury of rat carotid artery. Clopigrel does not affect platelet aggregation in vitro ; actually, its in vivo activity is highly dependent on hepatic metabolism. The results of a CAPRIE trial (Clopidogrel versus Aspirin in patients at risk of ischemic events) demonstrated that Clopidogrel was well tolerated and more effective than aspirin.

Originator

Sanofi (France)

Uses

anthelmintic, antiparasitic, antimite

Uses

Sertraline metabolite

brand name

Plavix (Sanofi Aventis);Plavix, Iscover.

General Description

Clopidogrel, methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (Plavix), is useful for the preventativemanagement of secondary ischemic events, including myocardialinfarction, stroke, and vascular deaths. It may beclassified as a thienopyridine because of its heterocyclicsystem. Several agents possessing this system have beenevaluated as potential antithrombotic agents. These agentshave a unique mechanism, in that they inhibit the purinergicreceptor located on platelets. Normally, nucleotides act asagonists on these receptors, which include the P2Y type.Two P2Y receptor subtypes (P2Y1 and P2Y2) found onplatelets, when stimulated by adenosine diphosphate (ADP),cause platelet aggregation.

Clinical Use

Clopidogrel acts as an antagonistto the P2Y2 receptor. It is probably a prodrug that requiresmetabolic activation, because in vitro studies do not interferewith platelet aggregation. Although platelet aggregationis not normally seen in the first 8 to 11 days after administrationto a patient, the effect lasts for several days after thedrug therapy is discontinued. Unlike other thienopyridinescurrently used, clopidogrel does not seriously reduce thenumber of white cells in the blood, and therefore, routinemonitoring of the white blood cell count is not necessaryduring treatment.

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ClopidogrelSupplierMore

Sichuan Ruibo Technology Co., Ltd
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+86-817-5586080
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3B Pharmachem (Wuhan) International Co.,Ltd.
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86-21-50328103 * 801、802、803、804 Mobile:18930552037
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3bsc@sina.com
Arden pharmaceutical &chemical Co., Ltd
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+86-(0)533-3595900 13793319233
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info@chems.com.cn
Chembest Research Laboratories Limited
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021-20908456-
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sales@BioChemBest.com
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel:
13817811078,021-50426030
Email:
sales@jingyan-chemical.com
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