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Sodium acetate trihydrate

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Sodium acetate trihydrate Basic information

Product Name:
Sodium acetate trihydrate
CAS:
6131-90-4
MF:
C2H9NaO5
MW:
136.08
EINECS:
612-115-9
Mol File:
6131-90-4.mol
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Sodium acetate trihydrate Chemical Properties

Melting point:
58 °C
Boiling point:
>400°C
Density 
1,45 g/cm3
Flash point:
>250°C
storage temp. 
Store at RT.
solubility 
H2O: 3 M at 20 °C, clear, colorless
form 
Solid
color 
White tranparent
Odor
Slight acetic acid
PH
7.5-9.0 (25℃, 50mg/mL in H2O)
PH Range
8.5 - 10 at 408 g/l at 25 °C
pka
4.76 (acetic acid)(at 25℃)
Water Solubility 
762 g/L (20 ºC)
λmax
λ: 260 nm Amax: ≤0.01
λ: 280 nm Amax: ≤0.01
Merck 
14,8571
BRN 
3732037
Stability:
Stable. Incompatible with strong oxidizing agents, halogens.
InChIKey
AYRVGWHSXIMRAB-UHFFFAOYSA-M
CAS DataBase Reference
6131-90-4(CAS DataBase Reference)
NIST Chemistry Reference
Sodium acetate trihydrate(6131-90-4)
EPA Substance Registry System
Acetic acid, sodium salt, trihydrate (6131-90-4)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
1
RTECS 
AJ4580000
Autoignition Temperature
607 °C
TSCA 
Yes
HS Code 
29152200
Toxicity
LD50 orally in Rabbit: 3530 mg/kg LD50 dermal Rabbit > 10000 mg/kg

MSDS

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Sodium acetate trihydrate Usage And Synthesis

Description

Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid.
In the food industry, sodium acetate is used as an acidity regulator, emulsifier, and preservative. It can give potato chips a salt and vinegar flavor. In pharmaceutical industry, it is used for replenishing lost electrolytes, as a diuretic, and in reusable heating pads and hand warmers. Sodium acetate trihydrate can be used to neutralize the industrial mineral acids discharge. In the textile and synthetic rubber production, it is used to neutralize sulfuric acids, facilitate aniline dye take up, and protect aniline day. In the leather industry, it is used as a buffering agent for leather tanning. Furthermore, sodium acetate trihydrate is used as buffers in the production of cosmetics and petroleum products and in electroplating industry.

Chemical Properties

white to colourless crystals or powder

Chemical Properties

Anhydrous salt is a colorless crystalline solid; density 1.528 g/cm3; melts at 324°C; very soluble in water; moderately soluble in ethanol. The colorless crystalline trihydrate has a density 1.45 g/cm3; decomposes at 58°C; is very soluble in water; pH of 0.1M aqueous solution is 8.9; moderately soluble in ethanol, 5.3 g/100mL.

Chemical Properties

Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.

Uses

Used as buffers.

Uses

Sodium acetate is a mordant in dyeing. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.

Preparation

Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate.
NaOH + CH3COOH → CH3COONa + H2O
Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O

Production Methods

Sodium acetate is prepared by neutralization of acetic acid with sodium carbonate.

Pharmaceutical Applications

Sodium acetate is used as part of a buffer system when combined with acetic acid in various intramuscular, intravenous, topical, ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It can be used to enhance the antimicrobial properties of formulations; it has been shown to inhibit the growth of S. aureus and E. coli, but not C. albicans in protein hydrolysate solutions. It is widely used in the food industry as a preservative. Sodium acetate has also been used therapeutically for the treatment of metabolic acidosis in premature infants, and in hemodialysis solutions.

Safety

Sodium acetate is widely used in cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
A short-term feeding study in chickens with a diet supplemented with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if injected intravenously, is moderately toxic by ingestion, and is an irritant to the skin and eyes.
LD50 (rat, oral): 3.53 g/kg
LD50 (mouse, IV): 0.38 g/kg
LD50 (mouse, SC): 8.0 g/kg

storage

Sodium acetate should be stored in airtight containers.

Incompatibilities

Sodium acetate reacts with acidic and basic components. It will react violently with fluorine, potassium nitrate, and diketene.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic, and oral preparations).

References

[1] http://www.europlat.org
[2] http://www.rxlist.com/sodium-acetate-drug.htm
[3] http://cosmetics.specialchem.com
[4] http://cecri.csircentral.net/2710/1/036-96.pdf

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Langfang Tianke Biological Technology Co., Ltd. Gold
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150-7665-966 0316-5569331-
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Jiangsu Kolod Food Ingredients Co.,Ltd. Gold
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Aikon International Limited Gold
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18068836627 025-58859352-
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sales01@aikonchem.com
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