ChemicalBook >  Product Catalog >  API >  Antipyretic analgesics >  Analgesics >  (+)-Bicuculline

(+)-Bicuculline

Basic information Safety Related Supplier

(+)-Bicuculline Basic information

Product Name:
(+)-Bicuculline
CAS:
485-49-4
MF:
C20H17NO6
MW:
367.35
EINECS:
207-619-7
Mol File:
485-49-4.mol
More
Less

(+)-Bicuculline Chemical Properties

Melting point:
193-197 °C
alpha 
D25 +130.5° (CHCl3)
Boiling point:
497.92°C (rough estimate)
Density 
1.3694 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
0-6°C
pka
4.84(at 25℃)
form 
Off-white to yellow powder.
optical activity
[α]20/D +126±6°, c = 1% in chloroform
λmax
325nm(lit.)
Merck 
14,1203
BRN 
98786
InChIKey
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference
485-49-4(CAS DataBase Reference)
EPA Substance Registry System
Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
More
Less

Safety Information

Hazard Codes 
T,N,Xn
Risk Statements 
23/24/25-50-36/37/38-20/21/22
Safety Statements 
36/37-45-61-36-26
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
LV0909840
10-23
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29399990
Toxicity
LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93
More
Less

(+)-Bicuculline Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

GABAA receptor antagonist.

Uses

GABAa antagonist

Uses

Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

Biological Activity

Classical GABA A antagonist.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.

Purification Methods

It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].

More
Less

(+)-BicucullineSupplierMore

Chembest Research Laboratories Limited Gold
Tel:
021-20908456-
Email:
sales@BioChemBest.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Ascent Scientific
Tel:
4401179829988
Email:
customerservice@ascentscientific.co.uk
Basic information Safety Related Supplier