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Acetamide

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Acetamide Basic information

Product Name:
Acetamide
CAS:
60-35-5
MF:
C2H5NO
MW:
59.07
EINECS:
200-473-5
Mol File:
60-35-5.mol
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Acetamide Chemical Properties

Melting point:
78-80 °C(lit.)
Boiling point:
221 °C(lit.)
Density 
1.159
vapor pressure 
1 mm Hg ( 65 °C)
refractive index 
1.4274
Flash point:
220-222°C
storage temp. 
Store at RT
solubility 
H2O: 0.5 g/mL, Hazen ≤50
pka
0.63(at 25℃)
form 
Crystals
color 
White
Water Solubility 
2000 g/L (20 ºC)
JECFA Number
1592
Merck 
14,43
BRN 
1071207
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
InChIKey
DLFVBJFMPXGRIB-UHFFFAOYSA-N
CAS DataBase Reference
60-35-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide(60-35-5)
EPA Substance Registry System
Acetamide (60-35-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
36/37
RIDADR 
UN 3077 9/PG 3
WGK Germany 
1
RTECS 
AB4025000
3
TSCA 
Yes
HS Code 
29241900
Hazardous Substances Data
60-35-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 7000 mg/kg

MSDS

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Acetamide Usage And Synthesis

Description

Acetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.

Chemical Properties

Acetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.

Chemical Properties

Acetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.

Uses

  1. Acetamide is often used as plasticizer and as industrial solvent.
  2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
  3. Solubilizer.
  4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
  5. stabilizer.
  6. manufacture of methylamine, denaturing alcohol.
  7. In organic syntheses.
  8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
  9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.

General Description

Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.

Air & Water Reactions

Deliquescent. Very soluble in water.

Reactivity Profile

Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).

Health Hazard

After oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.

Health Hazard

Mild irritant; acute oral toxicity in animals very low; oral LD50 value (rats):7000 mg/kg; carcinogenic to animals; oraladministration caused blood and liver tumorsin mice and rats; carcinogenicity: animal limited evidence, no evidence in humans.

Fire Hazard

The flash point of Acetamide has not been determined, but Acetamide is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Used as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing

storage

Acetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Purification Methods

Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]

Incompatibilities

Reacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.

Waste Disposal

Add to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.

Precautions

During handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.

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Shanghai Hao Yun Chemical Science Co.,Ltd. Gold
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021-68367562- ;021-68369562-
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J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
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sh@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:
3bsc@sina.com
Chembest Research Laboratories Limited
Tel:
021-20908456-
Email:
sales@BioChemBest.com
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