Titanocene dichloride Chemical Properties
- Melting point:
- 260-280 °C (dec.)(lit.)
- Boiling point:
- 355.52°C (estimate)
- 1.6 g/mL at 25 °C(lit.)
- storage temp.
- Store below +30°C.
- Specific Gravity
- Water Solubility
- slow decomposition
- Air & Moisture Sensitive
- Hydrolytic Sensitivity
- 4: no reaction with water under neutral conditions
- Stable. Incompatible with strong oxidizing agents. Decomposes in water. Moisture sensitive.
- CAS DataBase Reference
- 1271-19-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Titanocene dichloride(1271-19-8)
- EPA Substance Registry System
- Titanocene dichloride (1271-19-8)
Titanocene dichloride Usage And Synthesis
- Precatalyst for reduction of esters and α,β-unsaturated ketones.
- Catalyzes reductive deoxygenation of alcohols and hydroxylamines.
- Catalyst for the radical cyclization of epoxides.
- Reagent for the conversion of enynes to bicyclic cyclopentenones.
- Catalyzes silylation of alkenes and alkynes.
Titanocene dichloride is irritating to the skin and mucous membranes.
Red crystals. Moderately soluble in toluene, chloroform; sparingly soluble in ether and water. Stable in dry air, slowly hydrolyzed in moist air.
Catalyst; with aluminum alkyls as Ziegler-Natta polymerization catalyst.
Titanocene dichloride is used as an experimental cancer chemotherapeutic agent.
Titanocene dichloride is produced by the reaction of titanium tetrachloride with cyclopentadienyl sodium.
Red to red-orange crystals.
Air & Water Reactions
Stable in dry air. Decomposes in moist air and in water to form HCl .
Titanocene dichloride is incompatible with strong oxidizers. Titanocene dichloride may decompose on exposure to water. .
Toxic by inhalation, irritant to skin and mucous membranes.
Flash point data for Titanocene dichloride are not available; however, Titanocene dichloride is probably combustible.
Poison by intravenous and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Mutation data reported. See also TITANIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of Cl-
Based on the results of 2 year gavage studies, the National Toxicology Program determined that there was equivocal evidence of the carcinogenic activity of titanocene dichloride in male and female rats based on a marginal increase in the incidence of forestomach squamous cell effects.
Titanocene administered by intramuscular injection produced tumors both at the injection site and at sites distant from the injection site. Titanocene dichloride showed equivocal evidence of carcinogenicity in male and female Fischer 244 rats in a 2-year oral gavage study.
It forms bright red crystals from toluene or xylene/CHCl3 (1:1) and sublimes at 190o/2mm. It is moderately soluble in EtOH and insoluble in Et2O, *C6H6, CS2, CCl4, pet ether and H2O. The crystalline dipicrate explodes on melting at 139-140o. [Wilkinson et al. J Am Chem Soc 75 1011 1953, IR: Wilkinson & Birmingham J Am Chem Soc 76 4281 1954, NMR and X-ray: Glivicky & McCowan Can J Chem 51 2609 1973, Clearfield et al. J Am Chem Soc 53 1622 1975, Beilstein 16 IV 1769.]
- Titanous chloride
- Cobalt chloride
- METHYLCYCLOPENTADIENE DIMER
- Diisopropylammonium dichloroacetate
- 4,4'-Dichlorodiphenyl sulfone
- Bis(cyclopentadienyl)zirconium dichloride
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