2-Methoxynaphthalene Chemical Properties
- Melting point:
- 70-73 °C(lit.)
- Boiling point:
- 274 °C(lit.)
- 1.064 g/mL at 25 °C(lit.)
- 4704 | BETA-NAPHTHYL METHYL ETHER
- refractive index
- 1.5440 (estimate)
- Flash point:
- storage temp.
- Store below +30°C.
- H2O: soluble (completely)
- Crystalline Solid
- White to yellow-brown
- Water Solubility
- JECFA Number
- Stable. Combustible. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 93-04-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Naphthalene, 2-methoxy-(93-04-9)
- EPA Substance Registry System
- Naphthalene, 2-methoxy- (93-04-9)
- Safety Statements
- UN 3077 9 / PGIII
- WGK Germany
- HS Code
- LD50 oral in rat: > 5gm/kg
2-Methoxynaphthalene Usage And Synthesis
β-Naphthyl methyl ether has an intensely sweet, floral odor suggestive of orange blossoms. It is free from naphthol by-odor. It has a sweet, strawberry taste. This may be prepared from potassium β-naphthol and methyl chloride at 300°C; by methylation of β-naphthol with dimethyl sulfate or by direct esterification with methyl alcohol.
β-Naphthyl methyl ether has an intensely sweet, floral odor suggestive of orange blossoms; free from naphthol by-odor. It has a sweet, strawberry taste
Methyl 2-Naphthyl Ether forms white crystals (mp 73–74°C) with an intense orange blossom odor.
2-Methoxynaphthalene is an Impurity of the non-steroidal anti-inflammatory Naproxen (N377525).
From postassium β-naphthol and methyl chloride at 300°C; by methylation of β-naphthlol with dimethyl sulfate or by direct esterification with methyl alcohol
Preparation of 2-Methoxynaphthalene from 2-naphthol.
Principle: Phenols can be methylated to give methyl ethers. Methylation can be done either by using diazomethane or dimethyl sulphate in alkaline medium.
Procedure: Take 0.5 g 2-naphthol and 0.2 g NaOH in 5 ml distilled water in a beaker (25 ml). Heat on a wire gauze to obtain a clear solution. Cool the solution (10-15°C) and then add 0.35 ml dimethyl sulphate drop wise. After the addition is over, warm the mixture for one hour at 70-80°C and then cool. Filter the product and wash it with 10% sodium hydroxide solution and then with water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. Filter the white crystals of the product. Dry and record the melting point and TLC (using toluene as solvent).
Fractionally distil the ether under vacuum. Crystallise it from absolute EtOH, aqueous EtOH, *C6H6, pet ether or n-heptane, and dry it under vacuum in an Abderhalden pistol or distil it in vacuo. The picrate has m 118o (from EtOH or CHCl3). [Kikuchi et al. J Phys Chem 91 574 1987, Beilstein 6 III 2969, 6 IV 4257.]
2-Methoxynaphthalene Preparation Products And Raw materials
- Dimethyl ether
- Basic Violet 1
- dinaphthyl ether
- Polyethylene Glycol Monomethyl Ether
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