NEMONAPRIDE

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NEMONAPRIDE Basic information

Product Name:
NEMONAPRIDE
CAS:
75272-39-8
MF:
C21H26ClN3O2
MW:
387.9
Mol File:
75272-39-8.mol
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NEMONAPRIDE Chemical Properties

Melting point:
152-153°C
storage temp. 
Store at RT
CAS DataBase Reference
75272-39-8
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NEMONAPRIDE Usage And Synthesis

Description

Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.

Chemical Properties

Colourless Crystalline Solid

Originator

Yamanouchi (Japan)

Uses

Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.

Uses

A selective dopamine D2 receptor antagonist. Used as an antipsychotic

brand name

Emirace

Biological Activity

Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.

NEMONAPRIDE Preparation Products And Raw materials

Raw materials

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