ChemicalBook >  Product Catalog >  API >  Antipyretic analgesics >  Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >  Sulindac

Sulindac

Basic information Used in Particular Diseases Safety Related Supplier

Sulindac Basic information

Product Name:
Sulindac
CAS:
38194-50-2
MF:
C20H17FO3S
MW:
356.41
EINECS:
253-819-2
Mol File:
38194-50-2.mol
More
Less

Sulindac Chemical Properties

Melting point:
182-185°C
Boiling point:
581.6±50.0 °C(Predicted)
Density 
1.2581 (estimate)
storage temp. 
Store at RT
solubility 
Very slightly soluble in water, soluble in methylene chloride, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
form 
neat
pka
pKa (25°) 4.7
Water Solubility 
Soluble in water, methanol, ethanol.
λmax
327nm(0.05mol/L methanolic HCl)(lit.)
Merck 
14,8982
CAS DataBase Reference
38194-50-2(CAS DataBase Reference)
NIST Chemistry Reference
Sulindac(38194-50-2)
EPA Substance Registry System
1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)- (38194-50-2)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
22-63-42/43
Safety Statements 
-
RIDADR 
3249
WGK Germany 
3
RTECS 
NK8226000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29309090

MSDS

More
Less

Sulindac Usage And Synthesis

Used in Particular Diseases

Acute Gouty Arthritis:
Dosage and Frequency: 200 mg twice daily for 7–10 days

Chemical Properties

Yellow Crystalline Solid

Uses

A non-steroidal anti-inflammatory agent. An anti-inflammatory

Uses

Sulindac is a non-steroidal anti-inflammatory drug.

Definition

ChEBI: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the ara position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.

Indications

Sulindac (Clinoril) is chemically related to indomethacin and is generally used for the same indications. It is a prodrug that is metabolized to an active sulfide metabolite and an inactive metabolite. The most frequently reported side effects are GI pain, nausea, diarrhea, and constipation. The incidence of these effects is lower than for indomethacin, presumably because sulindac is a prodrug and thus the active metabolite is not highly concentrated at the gastric mucosa. As with indomethacin, a rather high incidence of CNS side effects (dizziness, headache) also occurs.

brand name

Clinoril (Merck).

General Description

Sulindac, (Z)-5-fluoro-2-methyl-1-([p-(methylsulfinyl)phenyl]methylene)-1H-indene-3-acetic acid (Clinoril), isan NSAID prodrug that contains a chiral sulfoxide moietybut is marketed as the racemate because it undergoes invivo reduction by the hepatic enzymes into its achiral, activemetabolite, methyl sulfide that exhibits potent andnonselective COX inhibition similar to indomethacin.
The parent sulfoxide has a plasma half-life of 8 hours, andthe active methyl sulfide metabolite is 16.4 hours. The morepolar and inactive sulfoxide is virtually the only form excretedinto the renal tubules, thus sulindac is believed to haveminimal nephrotoxicity associated with indomethacin. Thelong half-life of sulindac is caused by the extensive enterohepaticcirculation and reactivation of the inactive sulfoxideexcreted. Coadministration of aspirin is contraindicated becauseit considerably reduces the sulfide blood levels. Carefulmonitoring of patients with a history of ulcers is recommended.Gastric bleeding, nausea, diarrhea, dizziness, andother adverse effects have been noted with sulindac, but witha lower frequency than with aspirin. Sulindac is recommendedfor RA, OA, and ankylosing spondylitis.

Biological Activity

Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo . Widely used anti-inflammatory agent.

More
Less

SulindacSupplierMore

J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
INTATRADE GmbH
Tel:
+49 3493/605464
Email:
sales@intatrade.de
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:
3bsc@sina.com
Chembest Research Laboratories Limited
Tel:
021-20908456-
Email:
sales@BioChemBest.com
TAIYUAN RHF CO.,LTD.
Tel:
+86 351 7031519
Email:
sales@RHFChem.com
Basic information Used in Particular Diseases Safety Related Supplier