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Erythorbic Acid

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Erythorbic Acid Basic information

Product Name:
Erythorbic Acid
CAS:
89-65-6
MF:
C6H8O6
MW:
176.12
EINECS:
201-928-0
Mol File:
89-65-6.mol
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Erythorbic Acid Chemical Properties

Melting point:
169-172 °C (dec.)(lit.)
alpha 
-17.25 º (c=10, H2O 25 ºC)
Boiling point:
227.71°C (rough estimate)
Density 
1.3744 (rough estimate)
FEMA 
2410 | ERYTHROBIC ACID
refractive index 
-17.5 ° (C=10, H2O)
storage temp. 
Store at 0-5°C
solubility 
H2O: 0.1 g/mL, clear, colorless to very faintly yellow
form 
Crystals or Crystalline Powder
pka
4.09±0.10(Predicted)
color 
White to slightly yellow
optical activity
[α]25/D 16.8°, c = 2 in H2O
Water Solubility 
1g/10mL
Merck 
14,5126
BRN 
84271
Stability:
Stable. Combustible. Incompatible with chemically active metals, aluminium, zinc, copper, magnesium, strong bases, strong oxidizing agents.
InChIKey
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
CAS DataBase Reference
89-65-6(CAS DataBase Reference)
EPA Substance Registry System
Isoascorbic acid (89-65-6)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-24/25
WGK Germany 
2
RTECS 
KF3015000
TSCA 
Yes
HS Code 
29329990
Hazardous Substances Data
89-65-6(Hazardous Substances Data)

MSDS

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Erythorbic Acid Usage And Synthesis

Chemical Properties

Erythorbic acid occurs as a white or slightly yellow-colored crystals or powder. It gradually darkens in color upon exposure to light.

Uses

Antioxidant (industrial and food), especially in brewing industry, reducing agent in photography.

Uses

Erythorbic Acid is a food preservative that is a strong reducing agent (oxygen accepting) which functions similarly to antioxidants. In the dry crystalline state it is nonreactive, but in water solutions it reacts readily with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant. During preparation, dissolving and mixing should incorporate a minimum amount of air, and storage should be at cool temperatures. It has a solubility of 43 g/100 ml of water at 25°c. One part is equivalent to one part ascorbic acid and equivalent to one part sodium erythorbate. It is used to control oxidative color and flavor deterioration in fruits at 150–200 ppm. It is used in meat curing to speed and control the nitrite curing reaction and prolong the color of cured meat at levels of 0.05%.

Production Methods

Erythorbic acid is synthesized by the reaction between methyl 2- keto-D-gluconate and sodium methoxide. It can also be synthesized from sucrose, and produced from Penicillium spp.

Biotechnological Production

Yeasts and other fungi synthesize the C5 sugar acid D-erythroascorbic acid which shares structural and physicochemical properties with Asc. D-erythroascorbic acid serves similar protective functions in these microorganisms as Asc does in plants and animals, including the scavenging of reactive oxygen species. The biosynthesis of D-erythroascorbic acid starts from D-arabinose obtained by the microorganism from decaying plant material. D-arabinose, presumably in its 1,4-furanosidic isomeric form, is oxidized by NAD(P)+ specific dehydrogenases to D-arabinono-1,4-lactone, which is further oxidized to D-erythroascorbic acid by D-arabinono-1,4-lactone oxidase. Resting cells of Saccharomyces cerevisiae can synthesize Asc from L-galactose, L-galactono-1,4-lactone, or L-gulono- 1,4-lactone via the pathway naturally used for D-erythroascorbic acid.

Pharmaceutical Applications

Erythorbic acid is a stereoisomer of L-ascorbic acid, and is used as an antioxidant in foods and oral pharmaceutical formulations. It has approximately 5% of the vitamin C activity of L-ascorbic acid.

Safety

Erythorbic acid is widely used in food applications as an antioxidant. It is also used in oral pharmaceutical applications as an antioxidant. Erythorbic acid is generally regarded as nontoxic and nonirritant when used as an excipient. Erythorbic acid is readily metabolized and does not affect the urinary excretion of ascorbic acid.
The WHO has set an acceptable daily intake of erythorbic acid and its sodium salt in foods at up to 5 mg/kg body-weight.

storage

Erythorbic acid should be stored in an airtight container, protected from light, in a cool, dry place.

Purification Methods

Crystallise D(-)-isoascorbic acid from H2O, EtOH or dioxane. is at 245nm with 7,500 (EtOH). [Reichstein et al. Helv max Chim Acta 17 510, 516 1934, Heslop et al. J Chem Soc 225 1944, Beilstein 18 III/IV 3037, 18/5 V 26.]

Incompatibilities

Erythorbic acid is incompatible with chemically active metals such as aluminum, copper, magnesium, and zinc. It is also incompatible with strong bases and strong oxidizing agents.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral concentrate and tablets).

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Erythorbic AcidSupplierMore

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
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sh@meryer.com
Alfa Aesar
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400-610-6006; 021-67582000
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saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
BeiJing Hwrk Chemicals Limted
Tel:
010-57411839-
Email:
bjsales@hwrkchemical.com
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