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1,3-Dichloroacetone

Basic information Description Applications Safety Safety Related Supplier

1,3-Dichloroacetone Basic information

Product Name:
1,3-Dichloroacetone
CAS:
534-07-6
MF:
C3H4Cl2O
MW:
126.97
EINECS:
208-585-6
Mol File:
534-07-6.mol
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1,3-Dichloroacetone Chemical Properties

Melting point:
43 °C
Boiling point:
73 °C733.4 mm Hg(lit.)
Density 
1.383 g/mL at 25 °C(lit.)
vapor density 
4.38 (vs air)
vapor pressure 
<0.1 mm Hg ( 20 °C)
refractive index 
1.4400
Flash point:
193 °F
storage temp. 
Refrigerator (+4°C) + Poison room
solubility 
alcohol: very soluble
form 
Crystals
color 
White or colorless
Specific Gravity
1.383
PH
4.2 (10g/l, H2O, 20℃)
Water Solubility 
27.9 g/L (20 º C)
Merck 
14,3052
BRN 
605456
CAS DataBase Reference
534-07-6(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Dichloro-2-propanone(534-07-6)
EPA Substance Registry System
Bis(chloromethyl) ketone (534-07-6)
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Safety Information

Hazard Codes 
T+,F
Risk Statements 
24-26/28-34-68-36/37/38-11
Safety Statements 
26-36/37/39-45-28A-1-28-16
RIDADR 
UN 3286 3/PG 2
WGK Germany 
3
RTECS 
UC1430000
19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29147090
Hazardous Substances Data
534-07-6(Hazardous Substances Data)
Toxicity
mmo-sat 1250 ng/plate MUREAV 157,111,85

MSDS

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1,3-Dichloroacetone Usage And Synthesis

Description

1,3-Dichloroacetone is a chemical substance with the molecular formula C3H4Cl2O. TLC has discovered that it is a metabolite of 1,3-dichloropropanol. The crystalline solid is denser than water and is not water-soluble.

Applications

1,3-Dichloroacetone is employed in the synthesis of citric acid. Additionally, it is used as an intermediate and a solvent in organic synthesis. Furthermore, 1,3-Dichloroacetone is utilized as an acceptor substrate in the cross-aldol reaction with donor substrates such as clyclohexanone, cyclopentanone, and acetone. 1,3-Dichloroacetone is also employed in the preparation of famotidine which is an active pharmaceutical ingredient.

Safety

When exposed or inhaled, 1,3-Dichloroacetone can result in damage or irritation to eyes, lungs, throat, kidney, and kidneys. It can also lead to fainting and headaches. The substance has been classified as extremely hazardous in America.

Chemical Properties

White or colorless crystals

Chemical Properties

Bis(chhloromethyl)ketone is a crystalline solid.

General Description

A crystalline solid. Denser than water and insoluble in water. Inhalation of dust or powder may cause adverse health reactions.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Health Hazard

1,3-Dichloroacetone may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

When heated to decomposition, 1,3-Dichloroacetone emits highly toxic fumes of chlorides. 1,3-Dichloroacetone may burn but does not ignite readily. Container may explode in heat of fire.

Safety Profile

Poison by inhalation. Mutationdata reported. A systemic irritant by ingestion andinhalation routes. Dangerous; whenheated to decomposition it emits highly toxic fumes ofCl-.

Potential Exposure

Formerly extensively used in textiles (especially polyester fabrics) and still employed in polyurethane foams, textile backcoating and adhesives.

Shipping

UN2649 1,3-Dichloroacetone, Hazard class: 6.1; Labels: 6.1—Poisonous materials.

Purification Methods

Crystallise it from CCl4, CHCl3 or *benzene and/or distil under vacuum [Conant & Quayle Org Synth Coll Vol I 211 1941, Hall & Sirel J Am Chem Soc 74 836 1952]. It is dimorphic [Daasch & Kagarise J Am Chem Soc 77 6156 1955]. The oxime has m 130-131o, b 106o/25mm [Arzneimittel-Forsch 8 638 1958]. [Beilstein 1 IV 3219.]

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1,3-DichloroacetoneSupplierMore

Zhejiang ZETian Fine Chemicals Co. LTD
Tel:
+86-18957127338
Email:
stella@zetchem.com
Basic information Description Applications Safety Safety Related Supplier